(4-Bromoanilino)azanium;chloride

Base Information

• Chemical Name: (4-Bromoanilino)azanium;chloride
• CAS No.: 622-88-8
• Molecular Formula: C6H7BrN2^.HCl
• Molecular Weight: 223.5
• Hs Code.: 29280090
• Mol file: 622-88-8.mol

Synonyms:(4-bromoanilino)azanium;chloride

Chemical Property of (4-Bromoanilino)azanium;chloride

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.00278mmHg at 25°C
• Melting Point: 220-230 °C (dec.)(lit.)
• Boiling Point: 285.6 °C at 760 mmHg
• Flash Point: 126.5 °C
• PSA: 38.05000
• LogP: 3.31000
• Storage Temp.: Store below +30°C.
• Sensitive.: Hygroscopic
• Water Solubility.: Soluble in water.
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 221.95594
• Heavy Atom Count: 10
• Complexity: 79.1

Purity/Quality:

99% ^*data from raw suppliers

4-Bromophenylhydrazine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C, Xi, T
• Hazard Codes: C,Xi,T
• Statements: 34
• Safety Statements: 26-36/37/39-45-28A

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1N[NH3+])Br.[Cl-]
• Uses: 4-Bromophenylhydrazine hydrochloride is used as a reagent in the preparation of acylsulfonamides, acylsulfamides and 9-bromo-2-ethenyl-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one. 4-Bromophenylhydrazine hydrochloride was used as reagent in the synthesis of:acylsulfonamides and acylsulfamides9-bromo-2-ethenyl-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one

Technology Process of (4-Bromoanilino)azanium;chloride

There total 25 articles about (4-Bromoanilino)azanium;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%

4-bromo-aniline (106-40-1) → 4-bromophenylhydrazine hydrochloride (622-88-8,41931-18-4)

Guidance literature:

4-bromo-aniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h; Inert atmosphere;

With tin(ll) chloride; In water; at 20 ℃; for 3h; Inert atmosphere;

Reference yield: 72.0%

1.4-dibromobenzene (106-37-6) → 4-bromophenylhydrazine hydrochloride (622-88-8,41931-18-4)

Guidance literature:

1.4-dibromobenzene; With potassium phosphate; copper(l) iodide; N,N′-bis(2,6-dimethylphenyl)oxalamide; cetyltrimethylammonim bromide; In water; at 80 ℃; for 0.25h; Schlenk technique; Inert atmosphere; Sealed tube;

With hydrazine hydrate; In water; at 80 ℃; Inert atmosphere; Schlenk technique; Sealed tube;

With hydrogenchloride; In water; pH=3 - 4; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1002/cjoc.201800326

Reference yield: 41.0%

(4-bromophenyl)diazonium chloride (2028-85-5) → 4-bromophenylhydrazine hydrochloride (622-88-8,41931-18-4)

Guidance literature:

With hydrogenchloride; tin(ll) chloride; In water; at 0 - 4 ℃;

upstream raw materials:

phenylhydrazine

4-bromo-aniline

(4-bromophenyl)diazonium chloride

(3R,4S)-4-hydroxy-2-oxotetrahydrofuran-3-yl 2-(2-(4-bromophenyl)hydrazinyl)-2-oxoethanoate

Downstream raw materials:

1-(4-bromophenyl)-3-methyl-1H-pyrazole

(4-bromophenyl)diazonium chloride

2-[2-(4-Bromo-phenyl)-5-p-tolyl-2H-pyrazol-3-yl]-3-p-tolyl-3H-quinazolin-4-one

2-(4-Bromo-phenyl)-1,2-dihydro-phthalazin-1-ol

Refernces

• 1、 Guillemard, Lucas,Jacob, Nicolas,Wencel-Delord, Joanna. "Highly Efficient Synthesis of Hindered 3-Azoindoles via Metal-Free C-H Functionalization of Indoles". supporting information. p. 574 - 580. Retrieved 2020/02/13.
• 2、 -. "An electroluminescen compound and an electroluminescent device comprising the same". Paragraph 0390-0394. . Retrieved 2021/02/02.