5-Chloro-2-hydroxybenzohydrazide

Base Information

• Chemical Name: 5-Chloro-2-hydroxybenzohydrazide
• CAS No.: 5022-48-0
• Molecular Formula: C7H7 Cl N2 O2
• Molecular Weight: 186.598
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID80383469
• Wikidata: Q82175195
• Mol file: 5022-48-0.mol

Synonyms:5-chloro-2-hydroxybenzohydrazide;5022-48-0;5-Chloro-2-hydroxy-benzoic acid hydrazide;5-chloro-2-hydroxybenzoic acid hydrazide;5-Chlorosalicylhydrazide;Oprea1_533447;SCHEMBL3277584;DTXSID80383469;MIVLIGXZOGZELS-UHFFFAOYSA-N;BBL015495;MFCD01001347;STK073449;AKOS000202668;SB86048;AS-11536;CS-0308863;FT-0709829;EN300-13703;5-CHLORO-2-HYDROXY-BENZOICACIDHYDRAZIDE;A923720;Z71422317

Chemical Property of 5-Chloro-2-hydroxybenzohydrazide

Chemical Property:

• PSA: 75.35000
• Density: 1.465g/cm³
• LogP: 1.74030
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 186.0196052
• Heavy Atom Count: 12
• Complexity: 177

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Chloro-2-hydroxy-benzoic acid hydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)C(=O)NN)O

Technology Process of 5-Chloro-2-hydroxybenzohydrazide

There total 4 articles about 5-Chloro-2-hydroxybenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.2%

methyl 5-chloro-2-hydroxybenzoate (4068-78-4) → 5-chlorosalicylhydrazide (5022-48-0)

Guidance literature:

With hydrazine; In ethanol; for 8h; Heating / reflux;

Reference yield: 79.2%

methyl 5-chloro-2-hydroxybenzoate (4068-78-4) + hydrazine (302-01-2,78206-91-4,119775-10-9,75013-58-0) → 5-chlorosalicylhydrazide (5022-48-0)

Guidance literature:

In ethanol; for 6h; Heating / reflux;

Reference yield: 70.0%

5-chlorosalicylic acid ethyl ester (15196-83-5) → 5-chlorosalicylhydrazide (5022-48-0)

Guidance literature:

With hydrazine hydrate; In ethanol; for 6h; Reflux;

DOI:10.1002/cmdc.202100559

upstream raw materials:

methyl 5-chloro-2-hydroxybenzoate

hydrazine

5-chlorosalicylic acid ethyl ester

Refernces

• 1、 Nguyen, Ngoc-Hong,Vo, Van-Giau,Phan, Hoang-Vinh-Truong,Ngo, Thanh-The,Sichaem, Jirapast,Nguyen, Thi-Phuong,Nguyen, Huu-Hung,Pham, Duc-Dung,Nguyen, Tien-Cong,Nguyen, Van-Kieu,Duong, Thuc-Huy. "Design, modification of phyllanthone derivatives as anti-diabetic and cytotoxic agents". . p. 371 - 378. Retrieved 2020/07/13.
• 2、 Jesumoroti, Omobolanle J.,Faridoon,Mnkandhla, Dumisani,Isaacs, Michelle,Hoppe, Heinrich C.,Klein, Rosalyn. "Evaluation of novel N′-(3-hydroxybenzoyl)-2-oxo-2H-chromene-3-carbohydrazide derivatives as potential HIV-1 integrase inhibitors". . p. 80 - 88. Retrieved 2019/01/30.