C₁₆H₁₀N₂S

Base Information

• Chemical Name: C₁₆H₁₀N₂S
• CAS No.: 1446418-93-4
• Molecular Formula: C₁₆H₁₀N₂S
• Molecular Weight: 262.335
• Mol file: 1446418-93-4.mol

Synonyms:C₁₆H₁₀N₂S

Chemical Property of C₁₆H₁₀N₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of C₁₆H₁₀N₂S

There total 2 articles about C₁₆H₁₀N₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

4-bromobenzenecarbonitrile (623-00-7) + 2'-(2-thienyl)pyridine (3319-99-1) → 4-(5-(pyridin-2-yl)thiophen-2-yl)benzonitrile (1446418-92-3) + C16H10N2S (1446418-93-4)

Guidance literature:

With PdCl(1,4-bis(diphenylphosphino)butane)(C₃H₅); potassium acetate; In N,N-dimethyl acetamide; at 150 ℃; for 16h; regioselective reaction; Schlenk technique; Inert atmosphere; Green chemistry;

DOI:10.1039/c3cy00150d

Reference yield:

2-(5-bromothiophen-2-yl)pyridine (123784-07-6) → C16H10N2S (1446418-93-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium acetate; PdCl(1,4-bis(diphenylphosphino)butane)(C₃H₅) / N,N-dimethyl acetamide / 24 h / 150 °C / Schlenk technique; Inert atmosphere; Green chemistry

2: potassium acetate; PdCl(1,4-bis(diphenylphosphino)butane)(C₃H₅) / N,N-dimethyl acetamide / 16 h / 150 °C / Schlenk technique; Inert atmosphere; Green chemistry

With PdCl(1,4-bis(diphenylphosphino)butane)(C₃H₅); potassium acetate; In N,N-dimethyl acetamide;

DOI:10.1039/c3cy00150d

upstream raw materials:

4-bromobenzenecarbonitrile

2'-(2-thienyl)pyridine

2-(5-bromothiophen-2-yl)pyridine

Refernces