Fluphenazine decanoate

Base Information

• Chemical Name: Fluphenazine decanoate
• CAS No.: 5002-47-1
• Molecular Formula: C32H44F3N3O2S
• Molecular Weight: 591.781
• Hs Code.: 3003909090
• European Community (EC) Number: 225-672-4
• NSC Number: 169510
• UNII: FMU62K1L3C
• DSSTox Substance ID: DTXSID7023069
• Nikkaji Number: J13.702B
• Wikidata: Q27278080
• NCI Thesaurus Code: C47996
• RXCUI: 25190
• Pharos Ligand ID: GAXGU4UL5JBJ
• Metabolomics Workbench ID: 67450
• ChEMBL ID: CHEMBL1200854
• Mol file: 5002-47-1.mol

Synonyms:fluphenazine decanoate;fluphenazine depot;ftorphenazine decanoate;liogen;mirenil;modecate;moditen depot;moditen-depot

Chemical Property of Fluphenazine decanoate

Chemical Property:

• Vapor Pressure: 3.4E-17mmHg at 25°C
• Melting Point: 30-32°
• Refractive Index: 1.537
• Boiling Point: 658.1 °C at 760 mmHg
• PKA: 7.32±0.10(Predicted)
• Flash Point: 351.8 °C
• PSA: 61.32000
• Density: 1.149 g/cm³
• LogP: 7.94050
• Solubility.: Practically insoluble in water, very soluble in ethanol and in methylene chloride, freely soluble in methanol.
• XLogP3: 9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 16
• Exact Mass: 591.31063331
• Heavy Atom Count: 41
• Complexity: 765

Purity/Quality:

FluphenazineDecanoate(~90%) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCCCCCCCCC(=O)OCCN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F
• Recent ClinicalTrials: CATIE- Schizophrenia Trial
• Uses: Fluphenazine Decanoate is used in psychotropic drug treatments like those relating to schizophrenia. Antipsychotic.
• Clinical Use: AntipsychoticSchizophrenia and other psychoses
• Drug interactions: Potentially hazardous interactions with other drugs Anaesthetics: enhanced hypotensive effect. Analgesics: increased risk of convulsions with tramadol; enhanced hypotensive and sedative effects with opioids. Anti-arrhythmics: increased risk of ventricular arrhythmias with anti-arrhythmics that prolong the QT interval; increased risk of ventricular arrhythmias with amiodarone and dronedarone - avoid; increased risk of ventricular arrhythmias with disopyramide.Antibacterials: increased risk of ventricular arrhythmias with delamanid and moxifloxacin - avoid Antidepressants: increased risk of ventricular arrhythmias with tricyclics, citalopram, escitalopram; possible increased risk of convulsions with vortioxetineAntiepileptics: antagonises anticonvulsant effect.Antimalarials: increased risk of ventricular arrhythmias with artenimol with piperaquine and artemether/lumefantrine - avoid.Antipsychotics: increased risk of ventricular arrhythmias with droperidol, pimozide and risperidone - avoid; avoid use of depot formulations with clozapine (cannot be withdrawn quickly if neutropenia occurs).Antivirals: increased risk of ventricular arrhythmias with saquinavir - avoid; concentration possibly increased with ritonavir.Anxiolytics and hypnotics: increased sedative effectsAtomoxetine: increased risk of ventricular arrhythmias.Beta-blockers: enhanced hypotensive effect; increased risk of ventricular arrhythmias with sotalolCytotoxics: increased risk of ventricular arrhythmias with arsenic trioxideDiuretics: enhanced hypotensive effect.Lithium: increased risk of extrapyramidal side effects and possibly neurotoxicity.Pentamidine: increased risk of ventricular arrhythmias - avoid.Avoid with drugs that prolong the QT interval.

Technology Process of Fluphenazine decanoate

There total 1 articles about Fluphenazine decanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ Fluphenazine decanoate (5002-47-1)

Guidance literature:

4-<3-(2-Trifluormethyl-phenothiazinyl-(10))-propyl>-1-(2-hydroxy-ethyl)-piperazin, Decanoylchlorid;

DOI:10.1021/jm00340a002