methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate

Base Information

• Chemical Name: methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate
• CAS No.: 30365-63-0
• Molecular Formula: C₂₇H₄₂O₄
• Molecular Weight: 430.628
• Mol file: 30365-63-0.mol

Synonyms:methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate

Chemical Property of methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate

Chemical Property:

Purity/Quality:

99%+, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate

There total 2 articles about methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate (4472-02-0) + sodium ethanolate (141-52-6) + hydrazine hydrate (7803-57-8,79785-97-0) → methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate (30365-63-0) + methyl 3α-acetoxy-5β-chol-11-ene-24-oate (2242-12-8)

Guidance literature:

at 170 ℃; Behandeln des Reaktionsprodukts mit Diazomethan in Aether und Behandeln des danach isolierten Reaktionsprodukts mit Acetanhydrid und Pyridin;

DOI:10.1002/hlca.19430260218

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + 3α-acetoxy-11β-hydroxy-5β-cholan-24-oic acid methyl ester (7751-05-5) + acetic acid (64-19-7,77671-22-8) → methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate (30365-63-0) + methyl 3α-acetoxy-5β-chol-11-ene-24-oate (2242-12-8)

Guidance literature:

Behandeln des Reaktionsprodukts mit Diazomethan in Aether und Behandeln des danach isolierten Reaktionsprodukts mit Acetanhydrid und Pyridin;

DOI:10.1002/hlca.19430260220

Reference yield: 63.0%

methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate (30365-63-0) → C31H50O6 (1311972-67-4) + methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate (4472-02-0)

Guidance literature:

methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate; With tert.-butylhydroperoxide; sodium hypochlorite; In water; ethyl acetate; at 0 - 5 ℃; for 7h;

With sodium sulfite; In ethyl acetate;

With pyridinium chlorochromate; In ethyl acetate; Product distribution / selectivity;

upstream raw materials:

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

sodium ethanolate

hydrazine hydrate

hydrogenchloride

Downstream raw materials:

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

3α-acetoxy-9,11β-epoxy-5β,9β-cholan-24-oic acid methyl ester

Deoxycholic acid

C₃₁H₅₀O₆