CID 53629023

Base Information

• Chemical Name: CID 53629023
• CAS No.: 2786-07-4
• Molecular Formula: C4H3LiS
• Molecular Weight: 90.0748
• Hs Code.: 2934999090
• Nikkaji Number: J150.205K
• Mol file: 2786-07-4.mol

Synonyms:

Chemical Property of CID 53629023

Chemical Property:

• Flash Point: −22 °F
• PSA: 28.24000
• Density: 0.829 g/mL at 25 °C
• LogP: 1.54830
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 90.01154970
• Heavy Atom Count: 6
• Complexity: 26.8

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Thienyl-lithium ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,Xi
• Hazard Codes: F,Xi,N,Xn
• Statements: 11-14/15-19-36/37/38-67-65-62-51/53-48/20-40-14
• Safety Statements: 16-26-27-36/37/39-45-62-61-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: [Li].C1=CS[C]=C1
• Uses: 2-Thienyl-lithium is a useful building block for organic synthesis.

Technology Process of CID 53629023

There total 7 articles about CID 53629023 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

thiophene (188290-36-0,8014-23-1,25233-34-5) → 2-thienyl lithium (2786-07-4)

Guidance literature:

With tetrahydrofuran; lithium; at -196.15 ℃;

DOI:10.1002/ejic.200400423

Reference yield:

thiophene (188290-36-0,8014-23-1,25233-34-5) + n-butyllithium (109-72-8,29786-93-4) → 2-thienyl lithium (2786-07-4)

Guidance literature:

DOI:10.1021/ja01140a057

Reference yield:

2-bromothiophene (1003-09-4) → 2-thienyl lithium (2786-07-4)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -70 ℃;

DOI:10.1021/jo970778b

upstream raw materials:

thiophene

n-butyllithium

2-bromothiophene

2-Iodothiophene

Downstream raw materials:

2-thiophen-2-yl-quinoline

thiophene boronic acid

2-methyl-2-phenyl-1-[2]thienyl-propan-1-one

2-ethyl-2-phenyl-1-[2]thienyl-butan-1-one

Refernces

• 1、 Mendoza, Oscar,Rehmann, Franz-Josef K.,Cuffe, Laurence P.,Tacke, Matthias. "Cocondensation reactions of five-membered heterocycles with lithium atoms at 77 K". . p. 4525 - 4532. Retrieved 2004.
• 2、 Tiecco, Marcello,Testaferri, Lorenzo,Bagnoli, Luana,Marini, Francesca,Temperini, Andrea,Tomassini, Cristina,Santi, Claudio. "Electrophilic 2-thienylselenenylation of thiophene. Preparation of oligo(seleno-2,5-thienylenes)". . p. 3255 - 3260. Retrieved 2000.
• 3、 He, Tao,Li, Bin,Liu, Lichuan,Ma, Wenpeng,He, Wei. "Rhodium-Catalyzed Intermolecular Silylation of Csp?H by Silacyclobutanes". supporting information. p. 5648 - 5652. Retrieved 2021/03/08.
• 4、 Minami, Yasunori,Noguchi, Yuta,Hiyama, Tamejiro. "Synthesis of Benzosiloles by Intramolecular anti-Hydroarylation via ortho-C-H Activation of Aryloxyethynyl Silanes". supporting information. p. 14013 - 14016. Retrieved 2017/10/17.