POLY-GAMMA-BENZYL L-GLUTAMATE

Base Information

• Chemical Name: POLY-GAMMA-BENZYL L-GLUTAMATE
• CAS No.: 25014-27-1
• Molecular Formula: C12H15NO4
• Molecular Weight: 237.26
• Mol file: 25014-27-1.mol

Synonyms:POLY-GAMMA-BENZYL L-GLUTAMATE;POLY(GAMMA-BENZYL-L-GLUTAMIC ACID);POLY-G-BENZYL-L-GLUTAMATE;POLY-GAMMA-BENZYL L-GLUTAMATE MW 30000-70000;POLY-GAMMA-BENZYL L-GLUTAMATE*MOL WT 150 00-30000;POLY-GAMMA-BENZYL L-GLUTAMATE*MOL WT 150 000-350000;POLY-GAMMA-BENZYL L-GLUTAMATE*MOL WT 700 00-150000;POLY(.GAMMA.-BZ-GLU)

Chemical Property of POLY-GAMMA-BENZYL L-GLUTAMATE

Chemical Property:

• Boiling Point: 426.1°Cat760mmHg
• Flash Point: 211.5°C
• PSA: 89.62000
• Density: 1.245g/cm³
• LogP: 1.62220
• Storage Temp.: −20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Poly-γ-benzyl-L-glutamate mol wt 70,000-150,000 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of POLY-GAMMA-BENZYL L-GLUTAMATE

There total 23 articles about POLY-GAMMA-BENZYL L-GLUTAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Z(OMe)-Glu(OBzl)-OH (23506-06-1) → L-glutamic acid γ-benzyl ester (1676-73-9,25014-27-1)

Guidance literature:

With methanesulfonic acid; 3-methyl-phenol; In dichloromethane; at 25 ℃; for 0.5h;

DOI:10.1248/cpb.41.954

Reference yield: 95.31%

L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) + benzyl alcohol (100-51-6,185532-71-2) → L-glutamic acid γ-benzyl ester (1676-73-9,25014-27-1) + 1-benzyl L-glutamate (13030-09-6)

Guidance literature:

With copper dichloride; at 60 ℃; for 2h; Reagent/catalyst; Solvent; Temperature; Catalytic behavior; Mechanism;

DOI:10.1016/j.catcom.2014.01.014

Reference yield: 94.0%

L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) + benzyl alcohol (100-51-6,185532-71-2) → L-glutamic acid γ-benzyl ester (1676-73-9,25014-27-1)

Guidance literature:

With tetrafluoroboric acid diethyl ether; sodium sulfate; for 15h; Ambient temperature;

DOI:10.1055/s-1987-28030

upstream raw materials:

L-glutamic acid

toluene-4-sulfonic acid

benzyl alcohol

benzenesulfonic acid

Downstream raw materials:

N-trityl-L-glutamic acid-5-benzyl ester

benzyl N-tert-butyloxycarbonyl-L-γ-glutamate α-amide

(S)-2-((S)-2-{(2S,3S)-2-[2-(2-Chloro-benzyloxycarbonylamino)-acetylamino]-3-methyl-pentanoylamino}-3-methyl-butyrylamino)-pentanedioic acid 5-benzyl ester

bis(γ-benzyl) (benzyloxycarbonyl-α-L-glutamyl)-L-glutamate

Refernces

• 1、 -. "Preparation method of N-fluorenylmethoxycarbonyl-gamma-(S-triphenylmethyl-cysteamine)-L-glutamic acid". Paragraph 0061. . Retrieved 2020/10/05.
• 2、 -. "SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF". Page/Page column 36. . Retrieved 2019/08/26.