Technology Process of Benzeneethanamine, 5-benzyloxy-2-fluoro-beta-hydroxy-
There total 6 articles about Benzeneethanamine, 5-benzyloxy-2-fluoro-beta-hydroxy- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: H2, Et3N / PtO2 / methanol
2: 1.) sodium nitrite, H2SO4, 2.) Cu(NO3)2, Cu2O / 1.) H2O, 0-5 deg C, 5 min, 2.) H2O
3: 76 percent / K2CO3 / acetone / Ambient temperature
4: 1.) ZnI2, 2.) LiAlH4 / 1.) overnight, 2.) ether, reflux, 3 h
With
copper(I) oxide; lithium aluminium tetrahydride; sulfuric acid; hydrogen; potassium carbonate; copper(II) nitrate; triethylamine; zinc(II) iodide; sodium nitrite;
platinum(IV) oxide;
In
methanol; acetone;
DOI:10.1021/jm00160a030
- Guidance literature:
-
Multi-step reaction with 4 steps
1: imidazole / dimethylformamide
2: 1.) sec-BuLi, 2.) tetrabutylammonium fluoride / 1.) THF, hexane, -77 deg C, 0.5 h, 2.) THF, hexane, from -77 deg C to RT
3: 76 percent / K2CO3 / acetone / Ambient temperature
4: 1.) ZnI2, 2.) LiAlH4 / 1.) overnight, 2.) ether, reflux, 3 h
With
1H-imidazole; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; sec.-butyllithium; potassium carbonate; zinc(II) iodide;
In
N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00160a030
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 76 percent / K2CO3 / acetone / Ambient temperature
2: 1.) ZnI2, 2.) LiAlH4 / 1.) overnight, 2.) ether, reflux, 3 h
With
lithium aluminium tetrahydride; potassium carbonate; zinc(II) iodide;
In
acetone;
DOI:10.1021/jm00160a030