3-methoxy-2-phenylacrylonitrile

Base Information

• Chemical Name: 3-methoxy-2-phenylacrylonitrile
• CAS No.: 73591-08-9
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.188
• Mol file: 73591-08-9.mol

Synonyms:3-methoxy-2-phenylacrylonitrile

Chemical Property of 3-methoxy-2-phenylacrylonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-methoxy-2-phenylacrylonitrile

There total 3 articles about 3-methoxy-2-phenylacrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-hydroxy-2-phenylacrylonitrile (22252-92-2) + dimethyl sulfate (77-78-1) → 3-methoxy-2-phenylacrylonitrile (73591-08-9)

Guidance literature:

3-hydroxy-2-phenylacrylonitrile; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 2h;

dimethyl sulfate; In tetrahydrofuran; at 40 ℃; for 12h;

Reference yield:

phenylacetonitrile (140-29-4) → 3-methoxy-2-phenylacrylonitrile (73591-08-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 12 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran / 2 h / 20 °C

2.2: 12 h / 40 °C

With sodium hydride; In tetrahydrofuran;

Reference yield:

→ 3-methoxy-2-phenylacrylonitrile (73591-08-9)

Guidance literature:

aus 3-Hydroxy-2-phenyl-acrylsaeurenitril, Methanol in Bzl. od. Toluol in Ggw. von Toluol-4-sulfonsaeure, Siedetemp. unter Abdest. des gebildeten Wassers;

upstream raw materials:

3-hydroxy-2-phenylacrylonitrile

dimethyl sulfate

phenylacetonitrile

Downstream raw materials:

2,4-diamino-5-phenyl pyrimidine

3-amino-2-phenyl-acrylonitrile

4-amino-5-phenylpyrimidine

6-amino-2-hydroxy-5-phenyl-nicotinonitrile

Refernces

• 1、 -. "THIENOPYRIMIDINONE DERIVATIVES AS mGluR1 ANTAGONISTS". Paragraph 0195; 0196. . Retrieved 2014/08/19.