2,5-Dichloro-4'-biphenylol

Base Information

• Chemical Name: 2,5-Dichloro-4'-biphenylol
• CAS No.: 53905-28-5
• Molecular Formula: C₁₂H₈Cl₂O
• Molecular Weight: 239.101
• Hs Code.: 2907199090
• UNII: 57V0Q05TMH
• DSSTox Substance ID: DTXSID0022351
• Nikkaji Number: J146.422A
• Wikidata: Q27115937
• Metabolomics Workbench ID: 67985
• Mol file: 53905-28-5.mol

Synonyms:2,5-Dichloro-4'-biphenylol;53905-28-5;4-(2,5-dichlorophenyl)phenol;4-HYDROXY-2',5'-DICHLOROBIPHENYL;2',5'-Dichloro-(1,1'-biphenyl)-4-ol;[1,1'-Biphenyl]-4-ol, 2',5'-dichloro-;(1,1'-Biphenyl)-4-ol, 2',5'-dichloro-;UNII-57V0Q05TMH;2',5'-dichlorobiphenyl-4-ol;57V0Q05TMH;BIDD:ER0150;2',5'-dichloro-4-biphenylol;2,5-Dichloro-4/'-biphenylol;SCHEMBL2280325;DTXSID0022351;CHEBI:34244;2,5-dichloro-4' -hydroxybiphenyl;MFCD00152406;AKOS002678185;2',5'-Dichloro[1,1'-biphenyl]-4-ol #;Q27115937

Chemical Property of 2,5-Dichloro-4'-biphenylol

Chemical Property:

• Melting Point: 74-78 °C
• Boiling Point: 347.1°Cat760mmHg
• PKA: 9.25±0.30(Predicted)
• Flash Point: 135.8°C
• PSA: 20.23000
• Density: 1.35g/cm³
• LogP: 4.36600
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 237.9952203
• Heavy Atom Count: 15
• Complexity: 202

Purity/Quality:

99%min ^*data from raw suppliers

2',5'-DICHLORO-4-BIPHENYLOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C2=C(C=CC(=C2)Cl)Cl)O

Technology Process of 2,5-Dichloro-4'-biphenylol

There total 3 articles about 2,5-Dichloro-4'-biphenylol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-phenol (106-41-2) + 2,5-dichlorobenzeneboronic acid (135145-90-3) → 2',5'-dichlorobiphenyl-4-ol (53905-28-5)

Guidance literature:

4-bromo-phenol; With di-isopropyl azodicarboxylate; triphenylphosphine; Wang resin; In tetrahydrofuran; at 20 ℃;

2,5-dichlorobenzeneboronic acid; With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 80 ℃;

With trifluoroacetic acid; In dichloromethane; for 0.166667h;

DOI:10.1016/S0968-0896(03)00303-1

Reference yield:

4-(2,5-Dichloro-phenyl)-oxepine → 2',5'-dichlorobiphenyl-4-ol (53905-28-5)

Guidance literature:

In dimethyl sulfoxide; for 72h; Yield given; Ambient temperature;

DOI:10.1021/jo00331a029

Reference yield:

→ 2',5'-dichlorobiphenyl-4-ol (53905-28-5)

Guidance literature:

p-Anisidin, p-Dichlorbenzol, Amylnitrit, Essigsaeure, BBr3;

upstream raw materials:

4-bromo-phenol

2,5-dichlorobenzeneboronic acid

Refernces

• 1、 Reich, Ieva L.,Reich, Hans J.. "Synthesis of Chlorinated and Brominated Biphenyl Oxides". . p. 3721 - 3727. Retrieved 2007/10/02.