C₅₇H₅₄Br₂O₆

Base Information

• Chemical Name: C₅₇H₅₄Br₂O₆
• CAS No.: 174536-25-5
• Molecular Formula: C₅₇H₅₄Br₂O₆
• Molecular Weight: 994.86
• Mol file: 174536-25-5.mol

Synonyms:C₅₇H₅₄Br₂O₆

Chemical Property of C₅₇H₅₄Br₂O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₇H₅₄Br₂O₆

There total 8 articles about C₅₇H₅₄Br₂O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-bromo-3-iodo-5-methylbenzene (116632-38-3) + 3,5-Bis-{2-[4-ethynyl-2-propyloxy-5-(tetrahydro-2H-pyran-2-yloxy)phenyl]ethynyl}toluene (174536-24-4) → C57H54Br2O6 (174536-25-5)

Guidance literature:

With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; at 55 ℃; for 14h;

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → C57H54Br2O6 (174536-25-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 90 percent / H(+) / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) room temp., 1 h

2: piperidine / PdCl₂(PPh₃)2, CuI / 96 h / 55 °C

3: piperidine / PdCl₂(PPh₃)2, CuI / 96 h / 55 °C

4: 96 percent / 1N aq. NaOH, / methanol; tetrahydrofuran / 0.5 h / Ambient temperature

5: piperidine / PdCl₂(PPh₃)2, CuI / 14 h / 55 °C

6: Bu₄NF / tetrahydrofuran / 2 h / Ambient temperature

7: 84 percent / piperidine / PdCl₂(PPh₃)2, CuI / 14 h / 55 °C

With piperidine; sodium hydroxide; tetrabutyl ammonium fluoride; hydrogen cation; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

5-bromo-2-iodo-4-propyloxyphenol (174536-21-1) → C57H54Br2O6 (174536-25-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 90 percent / H(+) / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) room temp., 1 h

2: piperidine / PdCl₂(PPh₃)2, CuI / 96 h / 55 °C

3: piperidine / PdCl₂(PPh₃)2, CuI / 96 h / 55 °C

4: 96 percent / 1N aq. NaOH, / methanol; tetrahydrofuran / 0.5 h / Ambient temperature

5: piperidine / PdCl₂(PPh₃)2, CuI / 14 h / 55 °C

6: Bu₄NF / tetrahydrofuran / 2 h / Ambient temperature

7: 84 percent / piperidine / PdCl₂(PPh₃)2, CuI / 14 h / 55 °C

With piperidine; sodium hydroxide; tetrabutyl ammonium fluoride; hydrogen cation; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; dichloromethane;

upstream raw materials:

1-bromo-3-iodo-5-methylbenzene

3,5-Bis-{2-[4-ethynyl-2-propyloxy-5-(tetrahydro-2H-pyran-2-yloxy)phenyl]ethynyl}toluene

3,4-dihydro-2H-pyran

5-bromo-2-iodo-4-propyloxyphenol

Downstream raw materials:

3,5-Bis-(2-{4-[2-(3-ethynyl-5-methylphenyl)ethynyl]-2-propyloxy-5-(tetrahydro-2H-pyran-2-yloxy)phenyl}ethynyl)toluene

3,5-Bis-[2-(4-{2-[3-methyl-5-(2-trimethylsilylethynyl)phenyl]ethynyl}-2-propyloxy-5-(tetrahydro-2H-pyran-2-yloxy)phenyl)ethynyl]toluene

Refernces