2,2,2-Triphenylacetophenone

Base Information

• Chemical Name: 2,2,2-Triphenylacetophenone
• CAS No.: 466-37-5
• Molecular Formula: C26H20O
• Molecular Weight: 348.444
• Hs Code.: 2914399090
• European Community (EC) Number: 207-375-1
• NSC Number: 2820,194
• UNII: 7E2R2AL4JY
• DSSTox Substance ID: DTXSID50196881
• Nikkaji Number: J63I
• Wikidata: Q72514688
• Mol file: 466-37-5.mol

Synonyms:Acetophenone,2,2,2-triphenyl- (7CI,8CI);Ethanone, tetraphenyl- (9CI);b-Benzopinacolone (6CI);1,2,2,2-Tetraphenyl-1-ethanone;1,2,2,2-Tetraphenylethanone;Benzopinacolone;NSC 194;NSC 2820;Phenyl tritylketone;Tetraphenylethanone;w,w,w-Triphenylacetophenone;

Chemical Property of 2,2,2-Triphenylacetophenone

Chemical Property:

• Appearance/Colour: white to beige powder
• Vapor Pressure: 4.55E-10mmHg at 25°C
• Melting Point: 182-184 °C(lit.)
• Refractive Index: 1.624
• Boiling Point: 498.4 °C at 760 mmHg
• Flash Point: 216.3 °C
• PSA: 17.07000
• Density: 1.128 g/cm³
• LogP: 5.90390
• Storage Temp.: Storage temperature: no restrictions.
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 6.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 348.151415257
• Heavy Atom Count: 27
• Complexity: 411

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,2,2-Triphenylacetophenone ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)C(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4
• Uses: 2,2,2-Triphenylacetophenone is an endocrine disrupter that is medicated through estrogen receptors.

Technology Process of 2,2,2-Triphenylacetophenone

There total 110 articles about 2,2,2-Triphenylacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tetraphenylethane-1,2-diol (464-72-2) → benzopinacolone (466-37-5)

Guidance literature:

With tellurium tetrachloride; In dichloromethane; Ambient temperature;

Reference yield: 100.0%

tetraphenyloxirane (470-35-9) → benzopinacolone (466-37-5)

Guidance literature:

With isocyanate de chlorosulfonyle; In dichloromethane; benzene; at 0 ℃;

Reference yield: 98.0%

1,1,2,2-tetraphenyl-1,2-bis(trimethylsilyloxy)ethane (22341-08-8) → benzopinacolone (466-37-5)

Guidance literature:

tetrafluoroboric acid diethyl ether; In dichloromethane; at 0 ℃; for 0.6h;

DOI:10.3891/acta.chem.scand.52-0114

upstream raw materials:

benzoic acid methyl ester

diethyl ether

triphenylmethyl sodium

methanol

Downstream raw materials:

triphenylmethane

1,2,2-triphenylethan-1-one

1,1,2,2-tetraphenylethylene

1,1,2,2-tetraphenylethane

Refernces

• 1、 Olah,Meidar. "". . p. 358. Retrieved 1978.
• 2、 Fry et al.. "". . p. 4743. Retrieved 1958.
• 3、 Nishinaga,Wakabayashi. "". . p. 913. Retrieved 1978.
• 4、 Ciszek, Benjamin,Fleischer, Ivana,Kathe, Prasad,Schmidt, Tanno A.. "Tandem Acid/Pd-Catalyzed Reductive Rearrangement of Glycol Derivatives". supporting information. p. 3641 - 3646. Retrieved 2020/03/25.
• 5、 Gómez-Martínez, Melania,Baeza, Alejandro,Alonso, Diego A.. "Pinacol Rearrangement and Direct Nucleophilic Substitution of Allylic Alcohols Promoted by Graphene Oxide and Graphene Oxide CO2H". . p. 1032 - 1039. Retrieved 2017/03/27.