6,7-Dimethylquinoxaline

Base Information

• Chemical Name: 6,7-Dimethylquinoxaline
• CAS No.: 7153-23-3
• Molecular Formula: C10H10N2
• Molecular Weight: 158.1998
• Hs Code.: 2933990090
• NSC Number: 62693
• DSSTox Substance ID: DTXSID60289672
• Nikkaji Number: J925.206A
• Wikidata: Q82027089
• ChEMBL ID: CHEMBL2143755
• Mol file: 7153-23-3.mol

Synonyms:6,7-Dimethylquinoxaline;7153-23-3;MLS002693408;NSC 62693;quinoxaline, 6,7-dimethyl-;NSC62693;6,7-dimethyl-quinoxaline;SCHEMBL2491011;CHEMBL2143755;DTXSID60289672;HMS3079J10;QUINOXALINE,6,7-DIMETHYL-;MFCD03931879;NSC-62693;AKOS022173498;SMR001559363;FT-0620867;A844209;A866419

Chemical Property of 6,7-Dimethylquinoxaline

Chemical Property:

• Vapor Pressure: 0.00598mmHg at 25°C
• Refractive Index: 1.617
• Boiling Point: 281.7 °C at 760 mmHg
• Flash Point: 119.3 °C
• PSA: 25.78000
• Density: 1.109 g/cm³
• LogP: 2.24660
• Storage Temp.: 2-8°C
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 158.084398327
• Heavy Atom Count: 12
• Complexity: 140

Purity/Quality:

99% ^*data from raw suppliers

6,7-Dimethylquinoxaline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=NC=CN=C2C=C1C

Technology Process of 6,7-Dimethylquinoxaline

There total 6 articles about 6,7-Dimethylquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Glyoxal (131543-46-9,107-22-2) + 4,5-dimethyl-1,2-phenylenediamine (3171-45-7) → 6,7-dimethylquinoxaline (7153-23-3)

Guidance literature:

With sodium metabisulfite; sodium hydrogensulfite; In water; at 20 - 80 ℃;

DOI:10.1021/jo9918448

Reference yield: 89.0%

ethanolamine (141-43-5) + 4,5-dimethyl-1,2-phenylenediamine (3171-45-7) → 6,7-dimethylquinoxaline (7153-23-3)

Guidance literature:

With cesiumhydroxide monohydrate; [(η⁶-p-cymene)₂Ru₂(2,7-bis(di-2-pyridinyl)-1,8-naphthyridine)Cl₂](PF₆)₂; oxygen; at 120 ℃; for 23h; Inert atmosphere; Molecular sieve;

DOI:10.1016/j.jorganchem.2014.10.028

Reference yield: 78.0%

glyoxal sodium bisulfite (517-21-5) + 4,5-dimethyl-1,2-phenylenediamine (3171-45-7) → 6,7-dimethylquinoxaline (7153-23-3)

Guidance literature:

With water; at 70 ℃; for 1h;

DOI:10.1039/a809838g

upstream raw materials:

glyoxal sodium bisulfite

4,5-dimethyl-1,2-phenylenediamine

Glyoxal

ethanolamine

Downstream raw materials:

6,7-dimethylquinoxaline 1-oxide

6,7-dimethyl-1,2,3,4-tetrahydroquinoxaline

6,7-dihydrocyclobuta[g]quinoxaline

Refernces

• 1、 Min, Jun Zhe,Yamamoto, Makoto,Yu, Hai-Fu,Higashi, Tatsuya,Toyo'Oka, Toshimasa. "Rapid and sensitive determination of the intermediates of advanced glycation end products in the human nail by ultra-performance liquid chromatography with electrospray ionization time-of-flight mass spectrometry". . p. 187 - 194. Retrieved 2012.
• 2、 Wu, Jiajun,Darcel, Christophe. "Iron-Catalyzed Hydrogen Transfer Reduction of Nitroarenes with Alcohols: Synthesis of Imines and Aza Heterocycles". . p. 1023 - 1036. Retrieved 2021/01/09.
• 3、 Liu, Luo-Yan,Qiao, Jennifer X.,Yeung, Kap-Sun,Ewing, William R.,Yu, Jin-Quan. "Meta C-H Arylation of Electron-Rich Arenes: Reversing the Conventional Site Selectivity". supporting information. p. 14870 - 14877. Retrieved 2019/10/02.