17alpha-Hydroxyprogesterone hexanoate;17alpha-Hydroxyprogesterone caproate

Base Information Edit

Chemical Name:17alpha-Hydroxyprogesterone hexanoate;17alpha-Hydroxyprogesterone caproate
CAS No.:630-56-8
Molecular Formula:C27H40O4
Molecular Weight:428.612
Hs Code.:2937230000
NSC Number:759612
ChEMBL ID:CHEMBL3039315
Mol file:630-56-8.mol

Synonyms:17alpha-Hydroxyprogesterone hexanoate;17alpha-Hydroxyprogesterone caproate;Spectrum_000907;Spectrum2_000530;Spectrum3_000461;Spectrum4_000011;Spectrum5_000834;BSPBio_002162;KBioGR_000381;KBioSS_001387;DivK1c_000028;SPECTRUM1500343;SPBio_000519;CHEMBL3039315;SCHEMBL21497316;HMS500B10;KBio1_000028;KBio2_001387;KBio2_003955;KBio2_006523;KBio3_001382;NINDS_000028;HMS1920F07;HMS2091L15;HMS3371O02;Pharmakon1600-01500343;CCG-39518;NSC759612;NSC-759612;IDI1_000028;NCGC00178787-01;SBI-0051412.P003;AB00052017_02;SR-05000002083;SR-05000002083-1;BRD-A29731977-001-02-9;3-AMINO-3-[3-(4-METHYL-PHENOXY)-PHENYL]-PROPIONICACID

Suppliers and Price of 17alpha-Hydroxyprogesterone hexanoate;17alpha-Hydroxyprogesterone caproate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Hydroxyprogesterone Caproate
50mg
$ 80.00

Sigma-Aldrich
Hydroxyprogesterone Caproate Pharmaceutical Secondary Standard; Certified Reference Material
300MG
$ 139.00

Sigma-Aldrich
Hydroxyprogesterone caproate United States Pharmacopeia (USP) Reference Standard
200mg
$ 366.00

Medical Isotopes, Inc.
Hydroxyprogesterone Caproate
1 g
$ 1275.00

DC Chemicals
Hydroxyprogesterone Caproate >98%
100 mg
$ 100.00

Crysdot
17-Caproxyprogesterone 98+%
5g
$ 139.00

Chemenu
17alpha-hydroxyprogesteronecaproate 98%
100g
$ 224.00

Cayman Chemical
Hydroxyprogesterone Caproate ≥98%
100mg
$ 69.00

Cayman Chemical
Hydroxyprogesterone Caproate ≥98%
250mg
$ 164.00

Cayman Chemical
Hydroxyprogesterone Caproate ≥98%
500mg
$ 276.00

Total 171 raw suppliers

Chemical Property of 17alpha-Hydroxyprogesterone hexanoate;17alpha-Hydroxyprogesterone caproate Edit

Chemical Property:

Appearance/Colour:White or almost White Crystalline power
Vapor Pressure:1.4E-11mmHg at 25°C
Melting Point:119 °C
Refractive Index:1.533
Boiling Point:536.4 °C at 760 mmHg
Flash Point:227.6 °C
PSA：60.44000
Density:1.1 g/cm³
LogP:5.96960
Storage Temp.:Sealed in dry,Room Temperature
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:5.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:428.29265975
Heavy Atom Count:31
Complexity:797

Purity/Quality:

99.00% ^*data from raw suppliers

Hydroxyprogesterone Caproate ^*data from reagent suppliers

Safty Information:

Pictogram(s): T
Hazard Codes:T
Statements: 61
Safety Statements: 53-22-36/37/39-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCC(=O)OC1(CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C)C(=O)C
Isomeric SMILES:CCCCCC(=O)O[C@@]1(CCC2[C@@]1(CCC3C2CCC4=CC(=O)CC[C@]34C)C)C(=O)C
Description Hydroxyprogesterone caproate is a synthetic steroid hormone that is similar to medroxyprogesterone acetate and megestrol acetate. It is an ester derivative of 17α-hydroxyprogesterone formed from caproic acid (hexanoic acid). Hydroxyprogesterone caproate was previously marketed under the trade name Delalutin by Squibb, which was approved by the U.S. Food and Drug Administration (FDA) in 1956 and withdrawn from marketing in 1999. The U.S. FDA approved Makena from KV Pharmaceutical (previously named as Gestiva) on February 4, 2011 for prevention of preterm delivery in women with a history of preterm delivery, sparking a pricing controversy.
Uses Hydroxyprogesterone caproate is a synthetic progestin used for the prevention of spontaneous preterm births in singleton pregnancies in women who have previously had a spontaneous preterm birth. Hydroxyprogesterone Caproate is a synthetic progestin that reduces the chances of pre-term birth in women and improves specific fetal outcomes.
Therapeutic Function Progestin
Clinical Use Hydroxyprogesterone caproate (Makena?) is used to reduce the risk of preterm birth in women with a singleton pregnancy who have a history of singleton spontaneous preterm birth. Hydroxyprogesterone caproate was designated an orphan drug by the US Food and Drug Administration (FDA) for this use in 2007. Efficacy of the drug for this use is based on improvement in the proportion of women who delivered at less than 37 weeks of gestation. Direct clinical benefit (e.g., improvement in neonatal morbidity and mortality) has not been established. While there are many risk factors for preterm birth, safety and efficacy of hydroxyprogesterone caproate have been demonstrated only in women with a prior spontaneous singleton birth. Hydroxyprogesterone is not intended for use in women with multiple gestations or other risk factors for preterm birth. The American College of Obstetricians and Gynecologists (ACOG) recommends that progesterone supplementation for the prevention of recurrent preterm birth be offered to women with a singleton pregnancy and a prior spontaneous preterm birth at less than 37 weeks of gestation due to spontaneous preterm labor or premature rupture of membranes. The ACOG also states that physicians should be able to prescribe Makena or compounded hydroxyprogesterone caproate based on accepted medical indications after discussion with the patient.

Technology Process of 17alpha-Hydroxyprogesterone hexanoate;17alpha-Hydroxyprogesterone caproate

There total 28 articles about 17alpha-Hydroxyprogesterone hexanoate;17alpha-Hydroxyprogesterone caproate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.1%