HexylMalonicAcid

Base Information

• Chemical Name: HexylMalonicAcid
• CAS No.: 3974-36-5
• Molecular Formula: C9H16O4
• Molecular Weight: 188.224
• Hs Code.: 2917190090
• Mol file: 3974-36-5.mol

Synonyms:Hexylmalonic acid;Hexyl-malonsaeure;2-n-hexyl malonic acid;Malonic acid,hexyl;2-hexylmalonic acid;Propanedioic acid,hexyl;

Chemical Property of HexylMalonicAcid

Chemical Property:

• Vapor Pressure: 6.03E-06mmHg at 25°C
• Boiling Point: 353.5°C at 760 mmHg
• Flash Point: 181.8°C
• PSA: 74.60000
• Density: 1.128g/cm³
• LogP: 1.74220

Purity/Quality:

98%min ^*data from raw suppliers

2-Hexylmalonicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of HexylMalonicAcid

There total 8 articles about HexylMalonicAcid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-n-hexyl malonic acid (3974-36-5)

Guidance literature:

With potassium hydroxide;

Reference yield:

Hexylmalonsaeure-dimethylester (122459-92-1) → 2-n-hexyl malonic acid (3974-36-5)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃;

DOI:10.1021/jacs.8b08190

Reference yield:

1-Iodohexane (638-45-9) → 2-n-hexyl malonic acid (3974-36-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 24 h / Reflux

2.1: sodium hydroxide / water / 4 h / Reflux

With sodium hydride; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1002/cmdc.202100032

upstream raw materials:

hexylmalonyl dichloride

Antimycinolactol A₁

n-octanoic acid chloride

Hexylmalonsaeure-dimethylester

Downstream raw materials:

2-aminooctanoic acid

1-phenyldecan-3-one

2-bromooctanoic acid

1-phenyldec-1-yn-3-one

Refernces

• 1、 Wang, Kuai,DIng, Zhengtian,Zhou, Zhijun,Kong, Wangqing. "Ni-Catalyzed Enantioselective Reductive Diarylation of Activated Alkenes by Domino Cyclization/Cross-Coupling". supporting information. p. 12364 - 12368. Retrieved 2018/10/05.