4-(2-((p-tolylsulfonyl)oxy)ethyl)-2,2':6',2''-terpyridinyl

Base Information

• Chemical Name: 4-(2-((p-tolylsulfonyl)oxy)ethyl)-2,2':6',2''-terpyridinyl
• CAS No.: 108295-43-8
• Molecular Formula: C₂₄H₂₁N₃O₃S
• Molecular Weight: 431.515
• Mol file: 108295-43-8.mol

Synonyms:4-(2-((p-tolylsulfonyl)oxy)ethyl)-2,2':6',2''-terpyridinyl

Chemical Property of 4-(2-((p-tolylsulfonyl)oxy)ethyl)-2,2':6',2''-terpyridinyl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-((p-tolylsulfonyl)oxy)ethyl)-2,2':6',2''-terpyridinyl

There total 6 articles about 4-(2-((p-tolylsulfonyl)oxy)ethyl)-2,2':6',2''-terpyridinyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

4-(2-hydroxyethyl)-2,2':6',2''-terpyridinyl (108295-40-5) + p-toluenesulfonyl chloride (98-59-9) → 4-(2-((p-tolylsulfonyl)oxy)ethyl)-2,2':6',2''-terpyridinyl (108295-43-8)

Guidance literature:

With triethylamine; In benzene; 1.) rt, 30 min 2.) reflux, 4 h;

DOI:10.1021/ja00247a021

Reference yield:

2-acetyl-4-methylpyridine (59576-26-0) → 4-(2-((p-tolylsulfonyl)oxy)ethyl)-2,2':6',2''-terpyridinyl (108295-43-8)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium tert-butoxide / tetrahydrofuran / 14 h / Ambient temperature

2: 76 percent / ammonium acetate / acetic acid; tetrahydrofuran / 4 h / Heating

3: 73 percent / 1.) nickel(II) dichloride hexahydrate 2.)sodium borohydride / ethanol / 1.) 10 min, rt 2.) reflux, 12 h

4: 28 percent / 1.) diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 1.) rt, 1 h 2.) 7 h

5: 44 percent / 1.)triethylamine / benzene / 1.) rt, 30 min 2.) reflux, 4 h

With ammonium acetate; sodium tetrahydroborate; n-butyllithium; potassium tert-butylate; triethylamine; diisopropylamine; nickel dichloride; In tetrahydrofuran; ethanol; hexane; acetic acid; benzene;

DOI:10.1021/ja00247a021

Reference yield:

3,3-bis(methylsulfanyl)-1-pyridin-2-ylprop-2-en-1-one (78570-34-0) → 4-(2-((p-tolylsulfonyl)oxy)ethyl)-2,2':6',2''-terpyridinyl (108295-43-8)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium tert-butoxide / tetrahydrofuran / 14 h / Ambient temperature

2: 76 percent / ammonium acetate / acetic acid; tetrahydrofuran / 4 h / Heating

3: 73 percent / 1.) nickel(II) dichloride hexahydrate 2.)sodium borohydride / ethanol / 1.) 10 min, rt 2.) reflux, 12 h

4: 28 percent / 1.) diisopropylamine, n-butyllithium / tetrahydrofuran; hexane / 1.) rt, 1 h 2.) 7 h

5: 44 percent / 1.)triethylamine / benzene / 1.) rt, 30 min 2.) reflux, 4 h

With ammonium acetate; sodium tetrahydroborate; n-butyllithium; potassium tert-butylate; triethylamine; diisopropylamine; nickel dichloride; In tetrahydrofuran; ethanol; hexane; acetic acid; benzene;

DOI:10.1021/ja00247a021

upstream raw materials:

4-(2-hydroxyethyl)-2,2':6',2''-terpyridinyl

p-toluenesulfonyl chloride

2-acetyl-4-methylpyridine

3,3-bis(methylsulfanyl)-1-pyridin-2-ylprop-2-en-1-one

Refernces