Linsidomine

Base Information

• Chemical Name: Linsidomine
• CAS No.: 33876-97-0
• Molecular Formula: C6H10 N4 O2
• Molecular Weight: 170.171
• UNII: 5O5U71P6VQ
• DSSTox Substance ID: DTXSID501026026
• Wikipedia: Linsidomine
• Wikidata: Q1130256
• NCI Thesaurus Code: C72628
• Metabolomics Workbench ID: 154211
• ChEMBL ID: CHEMBL1189150
• Mol file: 33876-97-0.mol

Synonyms:3-morpholino-sydnonimine;3-morpholino-sydnonimine monohydrochloride;3-morpholinosydnonimine hydrochloride;3-morpholinosydnonimine N-ethylcarbamide;3-morpholinosydonimine;5-amino-3-(4-morpholinyl)-1,2,3-oxadiazolium;Corvasal;CV 664;CV-664;linsidomine;N-morpholino sydnonimine;SIN-1 morpholine

Chemical Property of Linsidomine

Chemical Property:

• Appearance/Colour: solid off-white
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 67.28000
• Density: g/cm³
• LogP: -0.91150
• Storage Temp.: −20°C
• Solubility.: H2O: >10 mg/mL
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 170.08037557
• Heavy Atom Count: 12
• Complexity: 222

Purity/Quality:

99% ^*data from raw suppliers

3-Morpholinosydnonimine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1[N+]2=CC(=N)O[N-]2
• Uses: 3-Morpholinosydnonimine is a potent vasodilator that inhibits platelet aggregation and cysteine proteases.

Technology Process of Linsidomine

There total 2 articles about Linsidomine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-morpholin-4-yl-glycine nitrile; hydrochloride (26263-64-9) → 3-morpholinosydnonymine (33876-97-0)

Guidance literature:

Multistep reaction; (i) aq. HCl, NaNO₂, (ii) HCl, MeOH;

Reference yield:

1-aminomorpholine (4319-49-7) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + potassium cyanide (151-50-8) → 3-morpholinosydnonymine (33876-97-0)

Guidance literature:

Multistep reaction; (i) H₂O, (ii) NaNO₂, aq. HCl, (iii) HCl, MeOH;

Reference yield:

4-methylthio-2-oxobutanoic acid (583-92-6) + 3-morpholinosydnonymine (33876-97-0) → ethene (74-85-1)

Guidance literature:

In phosphate buffer; at 35 ℃; for 1.66667h; pH=7.4; Further Variations:; in presence of cytosols and microsomes; Product distribution; Kinetics;

DOI:10.1016/S0166-445X(99)00070-3

upstream raw materials:

1-aminomorpholine

formaldehyd

potassium cyanide

N-morpholin-4-yl-glycine nitrile; hydrochloride

Downstream raw materials:

ethene

N-morpholino-N-nitroso-amino acetonitrile