1-methoxy-2-(prop-1-en-2-yl)benzene

Base Information

• Chemical Name: 1-methoxy-2-(prop-1-en-2-yl)benzene
• CAS No.: 10278-02-1
• Molecular Formula: C₁₀H₁₂O
• Molecular Weight: 148.205
• Mol file: 10278-02-1.mol

Synonyms:2-(2-methoxyphenyl)propene

Chemical Property of 1-methoxy-2-(prop-1-en-2-yl)benzene

Chemical Property:

• Vapor Pressure: 0.248mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methoxy-2-(prop-1-en-2-yl)benzene

There total 20 articles about 1-methoxy-2-(prop-1-en-2-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-Methoxyacetophenone (579-74-8) + Methyltriphenylphosphonium bromide (1779-49-3) → 2-(2-methoxyphenyl)propene (10278-02-1)

Guidance literature:

Methyltriphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 2h; Inert atmosphere;

2-Methoxyacetophenone; In tetrahydrofuran; hexane; at 20 ℃; Inert atmosphere; Glovebox;

DOI:10.1002/adsc.201900749

Reference yield: 78.0%

isopropenylboronic acid (14559-87-6) + 2-bromoanisole (578-57-4) → 2-(2-methoxyphenyl)propene (10278-02-1)

Guidance literature:

With cis,cis,cis-tetrakis[(diphenylphosphanyl)methyl]cyclopentane; potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)); In xylene; at 130 ℃; for 20h;

DOI:10.1002/ejoc.200300627

Reference yield: 73.0%

4-iodoanisol (529-28-2) + 1-Methyl-1-(1'-methylethenyl)silacyclobutane (288321-56-2) → 2-(2-methoxyphenyl)propene (10278-02-1)

Guidance literature:

With tetrabutyl ammonium fluoride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1055/s-2000-6292

upstream raw materials:

methyl magnesium iodide

2-methoxybenzoic acid methyl ester

ethyl 2-methoxybenzoate

2-isopropenylphenol

Downstream raw materials:

(E)-2-(2-methoxy-phenyl)-1-nitro-propene

(R)-1-methoxy-2-(1-nitropropan-2-yl)benzene

1-(2,2-dibromo-1-methylcyclopropyl)-2-methoxybenzene

2-Methoxyacetophenone

Refernces

• 1、 Bergmann,Weizmann. "-". . p. 1327,1328 Anm.. Retrieved 1936.
• 2、 Peppe, Clovis,Lang, Ernesto Schulz,De Andrade, Fabiano Molinos,De Castro, Liérson Borges. "Indium(III) bromide-catalyzed chemioselective dimerization of vinylarenes". . p. 1723 - 1726. Retrieved 2004.
• 3、 Ohmura, Toshimichi,Kusaka, Satoshi,Torigoe, Takeru,Suginome, Michinori. "Iridium-Catalyzed C(sp3)?H Addition of Methyl Ethers across Intramolecular Carbon–Carbon Double Bonds Giving 2,3-Dihydrobenzofurans". supporting information. p. 4448 - 4453. Retrieved 2019/09/16.