C₂₅H₄₂O₄

Base Information

• Chemical Name: C₂₅H₄₂O₄
• CAS No.: 1289377-58-7
• Molecular Formula: C₂₅H₄₂O₄
• Molecular Weight: 406.606
• Mol file: 1289377-58-7.mol

Synonyms:C₂₅H₄₂O₄

Chemical Property of C₂₅H₄₂O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₄₂O₄

There total 10 articles about C₂₅H₄₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C22H38O4 (1289377-52-1) + 2,2-dimethoxy-propane (77-76-9) → C25H42O4 (1289377-58-7)

Guidance literature:

With toluene-4-sulfonic acid; In water; at 20 - 25 ℃; for 5h; Inert atmosphere;

DOI:10.1021/ol2007567

Reference yield:

C15H22O2 (1289377-46-3) → C25H42O4 (1289377-58-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide / 1,4-dioxane; water; tert-butyl alcohol / 20 - 25 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - -50 °C / Inert atmosphere

2.2: 3.17 h / -78 °C / Inert atmosphere

3.1: sodium tetrahydroborate; acetic acid / acetonitrile / 4 h / 20 - 25 °C / Inert atmosphere

3.2: 2 h / 20 - 25 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / water / 5 h / 20 - 25 °C / Inert atmosphere

With 2,6-dimethylpyridine; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; toluene-4-sulfonic acid; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile; tert-butyl alcohol;

DOI:10.1021/ol2007567

Reference yield:

(3S,4R)-1-Benzyloxy-4-methyl-hex-5-en-3-ol (909803-71-0) → C25H42O4 (1289377-58-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

1.2: 0 - 25 °C / Inert atmosphere

2.1: 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide / 1,4-dioxane; water; tert-butyl alcohol / 20 - 25 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - -50 °C / Inert atmosphere

3.2: 3.17 h / -78 °C / Inert atmosphere

4.1: sodium tetrahydroborate; acetic acid / acetonitrile / 4 h / 20 - 25 °C / Inert atmosphere

4.2: 2 h / 20 - 25 °C / Inert atmosphere

5.1: toluene-4-sulfonic acid / water / 5 h / 20 - 25 °C / Inert atmosphere

With 2,6-dimethylpyridine; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; sodium hydride; toluene-4-sulfonic acid; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile; tert-butyl alcohol;

DOI:10.1021/ol2007567

upstream raw materials:

(3S,4R)-1-Benzyloxy-4-methyl-hex-5-en-3-ol

(4R)-4-benzyl-3-[(2R)-2-methylpentanoyl]-1,3-oxazolidin-2-one

C₁₅H₂₂O₂

C₈H₁₇NO₂

Refernces