Morpholinophosphonic acid diphenyl ester

Base Information

• Chemical Name: Morpholinophosphonic acid diphenyl ester
• CAS No.: 7412-25-1
• Molecular Formula: C16H18NO4P
• Molecular Weight: 319.297
• Mol file: 7412-25-1.mol

Synonyms:Diphenyl 4-morpholinylphosphonate;4-Morpholinephosphonic acid,diphenyl ester;morpholin-4-yl-phosphonic acid diphenyl ester;Diphenyl morpholinophosphonate;OR&WLN: T6N DOTJ APO&Phosphonic acid,morpholino-,diphenyl ester;Morpholino-phosphonsaeure-diphenylester;

Chemical Property of Morpholinophosphonic acid diphenyl ester

Chemical Property:

• Vapor Pressure: 1.15E-07mmHg at 25°C
• Melting Point: 71-72 °C
• Boiling Point: 432°C at 760 mmHg
• PKA: -4.60±0.20(Predicted)
• Flash Point: 215°C
• PSA: 57.81000
• Density: 1.28g/cm³
• LogP: 3.52260

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Morpholinophosphonic acid diphenyl ester

There total 6 articles about Morpholinophosphonic acid diphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

morpholine (110-91-8,99108-56-2) + diphenyl hydrogen phosphate (838-85-7) → morpholinodiphenylphosphine oxide (7412-25-1)

Guidance literature:

diphenyl hydrogen phosphate; With trichloroacetonitrile; triphenylphosphine; In dichloromethane; at 20 ℃; for 0.5h;

morpholine; With triethylamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.5012/bkcs.2011.32.9.3486

Reference yield: 94.0%

morpholine (110-91-8,99108-56-2) + C19H22N2O3P(1+)*F6P(1-) → morpholinodiphenylphosphine oxide (7412-25-1)

Guidance literature:

In acetonitrile; at 80 ℃; for 2h;

DOI:10.1039/c6ob01854h

Reference yield: 90.0%

morpholine (110-91-8,99108-56-2) + diphenyl phosphoryl azide (26386-88-9) → morpholinodiphenylphosphine oxide (7412-25-1)

Guidance literature:

In N,N-dimethyl-formamide; at 120 ℃; for 12h; Schlenk technique; Green chemistry;

DOI:10.1039/c9ra03389k

upstream raw materials:

morpholine

chlorophosphoric acid diphenyl ester

diphenyl hydrogen phosphate

diphenyl phosphoryl azide

Downstream raw materials:

morpholin-4-yl-phosphonic acid monomethyl ester

N,N-oxydiethylene-O,O-dimethylphosphoramidate

morpholin-4-yl-phosphonic acid monophenyl ester

Diethyl 4-morpholidophosphate

Refernces

• 1、 Li, Bin-Jie,Simard, Ryan D.,Beauchemin, André M.. "O -Phthalaldehyde catalyzed hydrolysis of organophosphinic amides and other P(O)-NH containing compounds". supporting information. p. 8667 - 8670. Retrieved 2017/08/10.
• 2、 Kasemsuknimit, Atthapol,Satyender, Apuri,Chavasiri, Warinthorn,Jang, Doo Ok. "Efficient amidation and esterification of phosphoric acid using Cl 3CCN/ Ph3P". experimental part. p. 3486 - 3488. Retrieved 2012/01/13.