4-Ethylbiphenyl

Base Information

• Chemical Name: 4-Ethylbiphenyl
• CAS No.: 5707-44-8
• Molecular Formula: C14H14
• Molecular Weight: 182.265
• Hs Code.: 29029090
• Mol file: 5707-44-8.mol

Synonyms:Biphenyl,4-ethyl- (6CI,7CI,8CI);1-Ethyl-4-phenylbenzene;4-Ethyl-1,1'-biphenyl;NSC 60063;p-Ethylbiphenyl;

Chemical Property of 4-Ethylbiphenyl

Chemical Property:

• Vapor Pressure: 4.5E-17mmHg at 25°C
• Melting Point: 34-35.5 °C
• Refractive Index: 1.612
• Boiling Point: 287.889 °C at 760 mmHg
• Flash Point: 128.666 °C
• PSA: 0.00000
• Density: 0.972 g/cm³
• LogP: 3.91600
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Ethylbiphenyl ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediates of Liquid Crystals

Technology Process of 4-Ethylbiphenyl

There total 18 articles about 4-Ethylbiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-ethyl-1-iodobenzene (25309-64-2) + phenylboronic acid (98-80-6) → biphenyl (92-52-4,1594-86-1) + 4-ethylbiphenyl (5707-44-8)

Guidance literature:

With trans-1,2-Diaminocyclohexane; potassium tert-butylate; silver(I) acetate; In dimethyl sulfoxide; at 150 ℃; for 7.5h; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.09.127

Reference yield: 79.0%

ethylbenzene (100-41-4,27536-89-6) + phenylboronic acid (98-80-6) → 4-ethylbiphenyl (5707-44-8)

Guidance literature:

With silver hexafluoroantimonate; 1,1,1,3',3',3'-hexafluoro-propanol; N-fluorobis(benzenesulfon)imide; N,N-dimethyl-formamide; palladium dichloride; In water; at 60 ℃; for 24h; regioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1021/jacs.6b12907

Reference yield: 60.0%

p-fluorotoluene (352-32-9) + 4-ethyl-1-(propylthio)benzene (20807-85-6) + phenylmagnesium bromide (100-58-3) → 4-Methylbiphenyl (644-08-6) + 4-ethylbiphenyl (5707-44-8)

Guidance literature:

p-fluorotoluene; 4-ethyl-1-(propylthio)benzene; phenylmagnesium bromide; 1-[2-(diphenylphosphino)phenyl]ethanol; bis(acetylacetonate)nickel(II); In diethyl ether; at 25 ℃; for 4h;

With methanol; In diethyl ether; Product distribution / selectivity;

upstream raw materials:

phenylium

ethylbenzene

benzene

4-ethylphenyl p-toluenesulfonate

Downstream raw materials:

4-(4-ethyl-phenyl)-deoxybenzoin

1-(4-Biphenylyl)-1-methoxyethane

1-(4-Biphenylyl)-1,1-dimethoxyethane

3-(4-Ethylphenyl)-3,6,6-trimethoxycyclohexa-1,4-diene

Refernces

• 1、 Argouarch, Gilles. "Mild and efficient rhodium-catalyzed deoxygenation of ketones to alkanes". supporting information. p. 11041 - 11044. Retrieved 2019/07/31.
• 2、 Luan, Yu-Xin,Zhang, Tao,Yao, Wei-Wei,Lu, Ke,Kong, Lu-Yao,Lin, Yu-Tong,Ye, Mengchun. "Amide-ligand-controlled highly para-selective arylation of monosubstituted simple arenes with arylboronic acids". supporting information. p. 1786 - 1789. Retrieved 2017/02/15.