3-Chloro-2-hydroxy-5-nitropyridine

Base Information

• Chemical Name: 3-Chloro-2-hydroxy-5-nitropyridine
• CAS No.: 22353-38-4
• Molecular Formula: C5H3ClN2O3
• Molecular Weight: 174.543
• Hs Code.: 2933399090
• European Community (EC) Number: 835-020-6
• NSC Number: 349953
• DSSTox Substance ID: DTXSID10319731
• Wikidata: Q72451933
• Mol file: 22353-38-4.mol

Synonyms:3-chloro-2-hydroxy-5-nitropyridine;22353-38-4;3-Chloro-5-nitropyridin-2-ol;3-chloro-5-nitro-1H-pyridin-2-one;3-Chloro-5-nitro-2-pyridinol;3-Chloro-5-Nitro-Pyridin-2-ol;MFCD06656618;2(1H)-Pyridinone, 3-chloro-5-nitro-;3-Chloro-5-nitro-2-pyridone;3-chloro-5-nitro-2-hydroxypyridine;NSC349953;SCHEMBL1038613;SCHEMBL10651010;DTXSID10319731;GEO-03635;2-hydroxy-3-chloro-5-nitro pyridine;3-Chloro-5-nitro-2-hydroxy-pyridine;AKOS005072832;AKOS023246995;3-Chloro-5-nitropyridin-2-ol, 98%;AC-1779;FC-0605;NSC 349953;NSC-349953;3-chloranyl-5-nitro-1H-pyridin-2-one;SY022537;3-CHLORO-2-HYDROXY-5-NITRO PYRIDINE;AM20070287;C3185;CS-0043739;FT-0647460;EN300-80844;3-Chloro-2-hydroxy-5-nitropyridine, AldrichCPR;A816140;J-512285;Z1198169261

Chemical Property of 3-Chloro-2-hydroxy-5-nitropyridine

Chemical Property:

• Melting Point: 187-189 °C
• Refractive Index: 1.572
• Boiling Point: 375.712 °C at 760 mmHg
• PKA: 6.58±0.10(Predicted)
• Flash Point: 181.024 °C
• PSA: 78.94000
• Density: 1.664 g/cm³
• LogP: 1.87200
• Storage Temp.: Room temperature.
• Solubility.: soluble in Methanol
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 173.9832197
• Heavy Atom Count: 11
• Complexity: 276

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Chloro-2-hydroxy-5-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=O)NC=C1[N+](=O)[O-])Cl

Technology Process of 3-Chloro-2-hydroxy-5-nitropyridine

There total 1 articles about 3-Chloro-2-hydroxy-5-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

salicylhydroxamic acid (89-73-6) + 2,3-dichloro-5-nitropyridine (22353-40-8) → 2-Benzoxazolinone (59-49-4) + 3-chloro-2-hydroxy-5-nitropyridine (22353-38-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1016/j.tetlet.2016.11.064

Reference yield:

3-chloro-2-hydroxy-5-nitropyridine (22353-38-4) + p-Methoxybenzyl bromide (2746-25-0) → 3-chloro-1-(4-methoxy-benzyl)-5-nitro-1H-pyridin-2-one (1441762-89-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

3-chloro-2-hydroxy-5-nitropyridine (22353-38-4) + methyl trans-4-hydroxycyclohexane-1-carboxylate → (1s,4s)-methyl 4-(3-chloro-5-nitropyridin-2-yloxy)cyclohexanecarboxylate

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 180 ℃; for 1h; Microwave irradiation;

upstream raw materials:

salicylhydroxamic acid

2,3-dichloro-5-nitropyridine

Downstream raw materials:

2,3-dichloro-5-nitropyridine

2-bromo-3-chloro-5-nitropyridine

5-chloro-6-bromopyridine-3-ol

6-bromo-5-chloropyridin-3-amine

Refernces