Flufylline

Base Information

• Chemical Name: Flufylline
• CAS No.: 82190-91-8
• Molecular Formula: C₂₁H₂₄FN₅O₃
• Molecular Weight: 413.452
• Mol file: 82190-91-8.mol

Synonyms:Flufylline;Sgd 19578

Chemical Property of Flufylline

Chemical Property:

• Vapor Pressure: 6.42E-16mmHg at 25°C
• Boiling Point: 632.8°C at 760 mmHg
• Flash Point: 336.5°C
• PSA: 82.13000
• Density: 1.39g/cm³
• LogP: 1.10560

Purity/Quality:

99% ^*data from raw suppliers

Flufylline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Flufylline

There total 2 articles about Flufylline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

fluorobenzoylpiperidine hydrochloride + (4-fluorophenyl)-piperidin-4-ylmethanone (56346-57-7) + 7-(2-chloroethyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione (5878-61-5) → 7-[2-[4-(p-fluorobenzoyl)-piperidino]-ethyl]-theophylline (82190-91-8)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In tetrachloromethane; ethyl acetate;

Reference yield:

(4-fluorophenyl)-piperidin-4-ylmethanone (56346-57-7) + 7-(2-chloroethyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione (5878-61-5) → 7-[2-[4-(p-fluorobenzoyl)-piperidino]-ethyl]-theophylline (82190-91-8)

Guidance literature:

at 100 ℃; for 1h;

upstream raw materials:

(4-fluorophenyl)-piperidin-4-ylmethanone

7-(2-chloroethyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione

Refernces

• 1、 Thiele,Jahn,Geissmann,Zirngibl. "New biologically active theophylline derivatives. Synthesis and pharmacologic properties of flufylline and fluprofylline". . p. 1 - 4. Retrieved 2007/10/02.