CID 657192

Base Information

• Chemical Name: CID 657192
• CAS No.: 21535-47-7
• Molecular Formula: C18H20N2.HCl
• Molecular Weight: 300.831
• Hs Code.: 2933990090
• Mol file: 21535-47-7.mol

Synonyms:CHEBI:31843;AKOS026749945

Chemical Property of CID 657192

Chemical Property:

• Appearance/Colour: Off-white solid
• Vapor Pressure: 5.65E-07mmHg at 25°C
• Melting Point: >230 °C (dec.)
• Boiling Point: 411.3 °C at 760 mmHg
• Flash Point: 186.1 °C
• PSA: 6.48000
• Density: 1.18 g/cm3
• LogP: 3.88880
• Storage Temp.: 2-8°C
• Solubility.: H2O: 3.4 mg/mL
• Water Solubility.: Soluble in water, ethanol, methanol, and dimethylformamide.
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 300.1393264
• Heavy Atom Count: 21
• Complexity: 342

Purity/Quality:

99% ^*data from raw suppliers

Mianserin Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xn,Xi,T,F
• Statements: 22-39/23/24/25-23/24/25-11
• Safety Statements: 7-16-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: [H+].CN1CCN2C(C1)C3=CC=CC=C3CC4=CC=CC=C42.[Cl-]
• Uses: Mianserin hydrochloride is a tetracyclic antidepressant with an EEG and clinical activity profile similar to amitriptyline. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors. Mianserin hydrochloride is used as an antidepressant, antagonist, inverse agonist at 5-HT2 serotonin receptors, also blocks the H1 histamine receptor and the α2 adrenoceptor.
• Therapeutic Function: Serotonin antagonist, Antihistaminic
• Clinical Use: Antidepressant
• Drug interactions: Potentially hazardous interactions with other drugs Alcohol: increased sedative effect. Antibacterials: avoid with linezolid and tedizolid. Antidepressants: avoid with MAOIs and moclobemide. Antiepileptics: convulsive threshold possibly lowered; concentration reduced by carbamazepine, fosphenytoin, phenobarbital, phenytoin and primidone. Antimalarials: avoid with artemether/lumefantrine and piperaquine with artenimol. Safinamide: increased risk of hypertension and CNS excitation.

Technology Process of CID 657192

There total 1 articles about CID 657192 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Aminobenzyl alcohol (5344-90-1) + styrene oxide (96-09-3) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + ethanolamine (141-43-5) → Tolvin (21535-47-7,78684-62-5)

Guidance literature:

ethanolamine; With benzaldehyde; at 30 - 40 ℃; for 0.75h; under 20 Torr;

styrene oxide; at 90 - 140 ℃; for 2h;

2-Aminobenzyl alcohol; formaldehyd; Further stages;

Reference yield:

Tolvin (21535-47-7,78684-62-5) → 8-Hydroxymianserin (57257-81-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 54 percent / POCl₃ / 4 h / 100 °C

2: m-CPBA; TFA / CH₂Cl₂ / 2 h / 5 - 20 °C

3: conc. HCl / methanol / 2 h

With hydrogenchloride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; trichlorophosphate; In methanol; dichloromethane; 1: Formylation / 2: Oxidation / 3: Hydrolysis;

upstream raw materials:

2-Aminobenzyl alcohol

styrene oxide

formaldehyd

ethanolamine

Downstream raw materials:

8-Hydroxymianserin

Refernces