diallyl 2-benzyl-2-fluoro-3-oxosuccinate

Base Information

• Chemical Name: diallyl 2-benzyl-2-fluoro-3-oxosuccinate
• CAS No.: 155528-45-3
• Molecular Formula: C₁₇H₁₇FO₅
• Molecular Weight: 320.317
• Mol file: 155528-45-3.mol

Synonyms:diallyl 2-benzyl-2-fluoro-3-oxosuccinate

Chemical Property of diallyl 2-benzyl-2-fluoro-3-oxosuccinate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of diallyl 2-benzyl-2-fluoro-3-oxosuccinate

There total 1 articles about diallyl 2-benzyl-2-fluoro-3-oxosuccinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

allyl 3-allyloxycarbonyl-2-oxo-4-phenylbutanoate (125582-89-0) → diallyl 2-benzyl-2-fluoro-3-oxosuccinate (155528-45-3)

Guidance literature:

With sodium hydride; 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1016/S0040-4020(01)80770-5

Reference yield:

diallyl 2-benzyl-2-fluoro-3-oxosuccinate (155528-45-3) → 4-Phenyl-3-fluor-2-oxo-buttersaeure (3413-69-2)

Guidance literature:

With formic acid; triethylamine; tris(dibenzylideneacetone)dipalladium chloroform complex; triphenylphosphine; In tetrahydrofuran; for 24h; Ambient temperature;

DOI:10.1016/S0040-4020(01)80770-5

Reference yield:

diallyl 2-benzyl-2-fluoro-3-oxosuccinate (155528-45-3) → methyl 3-fluoro-2-oxo-4-phenylbutanoate

Guidance literature:

Multi-step reaction with 2 steps

1: HCOOH, Et₃N / Pd(dba)3CHCl₃*PPh₃ / tetrahydrofuran / 24 h / Ambient temperature

2: diethyl ether; tetrahydrofuran / 0 °C

With formic acid; triethylamine; tris(dibenzylideneacetone)dipalladium chloroform complex; triphenylphosphine; In tetrahydrofuran; diethyl ether;

DOI:10.1016/S0040-4020(01)80770-5

upstream raw materials:

allyl 3-allyloxycarbonyl-2-oxo-4-phenylbutanoate

Downstream raw materials:

4-Phenyl-3-fluor-2-oxo-buttersaeure

Refernces