Technology Process of (3S,4S)-trans-N-Boc-3-acetylthio-4-(4-phenoxybenzenesulfonamido)pyrrolidine
There total 12 articles about (3S,4S)-trans-N-Boc-3-acetylthio-4-(4-phenoxybenzenesulfonamido)pyrrolidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran;
at 20 ℃;
for 6h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C
2.1: sodium azide; ammonium chloride / water; methanol / 65 °C
3.1: lipase Amano AK-20 / tert-butyl methyl ether / 72 h / 20 °C / Enzymatic reaction
4.1: triethylamine / dichloromethane / 0 - 20 °C
5.1: N,N-dimethyl-formamide / 6 h / 105 °C / Inert atmosphere
6.1: lithium hydroxide; methanol / tetrahydrofuran / 0 - 20 °C
7.1: triphenylphosphine; water / tetrahydrofuran / 20 - 65 °C
7.2: 0 - 20 °C
8.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 6 h / 20 °C
With
methanol; sodium azide; water; ammonium chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; lithium hydroxide; diethylazodicarboxylate;
lipase Amano AK-20;
In
tetrahydrofuran; methanol; dichloromethane; tert-butyl methyl ether; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium azide; ammonium chloride / water; methanol / 65 °C
2.1: lipase Amano AK-20 / tert-butyl methyl ether / 72 h / 20 °C / Enzymatic reaction
3.1: triethylamine / dichloromethane / 0 - 20 °C
4.1: N,N-dimethyl-formamide / 6 h / 105 °C / Inert atmosphere
5.1: lithium hydroxide; methanol / tetrahydrofuran / 0 - 20 °C
6.1: triphenylphosphine; water / tetrahydrofuran / 20 - 65 °C
6.2: 0 - 20 °C
7.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 6 h / 20 °C
With
methanol; sodium azide; water; ammonium chloride; triethylamine; triphenylphosphine; lithium hydroxide; diethylazodicarboxylate;
lipase Amano AK-20;
In
tetrahydrofuran; methanol; dichloromethane; tert-butyl methyl ether; water; N,N-dimethyl-formamide;