Technology Process of (7R,9R)-5,6-pineno-5'-((5-tert-butyl-2-ethynylphenyl)ethynyl)-2,2'-bipyridine
There total 7 articles about (7R,9R)-5,6-pineno-5'-((5-tert-butyl-2-ethynylphenyl)ethynyl)-2,2'-bipyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
toluene;
for 5h;
Reflux;
Inert atmosphere;
DOI:10.1002/chem.201204216
- Guidance literature:
-
Multi-step reaction with 3 steps
1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere
2: copper(l) iodide; diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 12 h / 80 °C / Inert atmosphere
3: potassium hydroxide / toluene / 5 h / Reflux; Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; diisopropylamine; potassium hydroxide;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene;
1: |Sonogashira Cross-Coupling / 2: |Sonogashira Cross-Coupling;
DOI:10.1002/chem.201204216
- Guidance literature:
-
Multi-step reaction with 2 steps
1: copper(l) iodide; diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 12 h / 80 °C / Inert atmosphere
2: potassium hydroxide / toluene / 5 h / Reflux; Inert atmosphere
With
copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; diisopropylamine; potassium hydroxide;
In
N,N-dimethyl-formamide; toluene;
1: |Sonogashira Cross-Coupling;
DOI:10.1002/chem.201204216