5-Fluoro-8-Nitro Quinoline

Base Information

• Chemical Name: 5-Fluoro-8-Nitro Quinoline
• CAS No.: 152167-85-6
• Molecular Formula: C₉H₅FN₂O₂
• Molecular Weight: 192.149
• Mol file: 152167-85-6.mol

Synonyms:5-Fluoro-8-nitroquinoline;

Chemical Property of 5-Fluoro-8-Nitro Quinoline

Chemical Property:

• Vapor Pressure: 0.000335mmHg at 25°C
• Refractive Index: 1.654
• Boiling Point: 329.7 °C at 760 mmHg
• PKA: 0.22±0.29(Predicted)
• Flash Point: 153.2 °C
• PSA: 58.71000
• Density: 1.446 g/cm³
• LogP: 2.80530

Purity/Quality:

98%min ^*data from raw suppliers

5-Fluoro-8-Nitro Quinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Fluoro-8-nitroquinoline can be used to treat iron metabolic disorders.

Technology Process of 5-Fluoro-8-Nitro Quinoline

There total 4 articles about 5-Fluoro-8-Nitro Quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

→ 5-fluoro-8-nitroquinoline (152167-85-6)

Guidance literature:

Reference yield: 59.0%

5-fluoroquinoline (394-69-4) → 5-fluoro-8-nitroquinoline (152167-85-6)

Guidance literature:

With sulfuric acid; nitric acid; at 20 ℃; for 24h;

DOI:10.1248/bpb.20.646

Reference yield: 19.0%

acrylaldehyde diethyl acetal (3054-95-3) + 5-fluoro-2-nitroaniline (2369-11-1) → 5-fluoro-8-nitroquinoline (152167-85-6)

Guidance literature:

With sulfuric acid; arsenic pentoxide pentahydrate; In water; at 80 - 120 ℃; for 4.5h;

DOI:10.1016/j.jfluchem.2016.11.016

upstream raw materials:

5-fluoroquinoline

5-Aminoquinoline

acrylaldehyde diethyl acetal

5-fluoro-2-nitroaniline

Downstream raw materials:

8-amino-5-fluoroquinoline

Refernces

• 1、 -. "Novel Sulfonaminoquinoline Hepcidin Antagonists". Page/Page column 128. . Retrieved 2012/09/05.