methyl 2-(phenylsulfonylmethyl)-3-furoate

Base Information

• Chemical Name: methyl 2-(phenylsulfonylmethyl)-3-furoate
• CAS No.: 260357-07-1
• Molecular Formula: C₁₃H₁₂O₅S
• Molecular Weight: 280.301
• Mol file: 260357-07-1.mol

Synonyms:methyl 2-(phenylsulfonylmethyl)-3-furoate

Chemical Property of methyl 2-(phenylsulfonylmethyl)-3-furoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of methyl 2-(phenylsulfonylmethyl)-3-furoate

There total 1 articles about methyl 2-(phenylsulfonylmethyl)-3-furoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-bromomethylfuran-3-carboxylic acid methyl ester (53020-08-9) + sodium benzenesulfonate (873-55-2) → methyl 2-(phenylsulfonylmethyl)-3-furoate (260357-07-1)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 90.0%

methyl 2-(phenylsulfonylmethyl)-3-furoate (260357-07-1) → 2-(phenylsulfonylmethyl)-3-furoic acid (260357-08-2)

Guidance literature:

With sodium hydroxide; In ethanol;

Reference yield:

methyl 2-(phenylsulfonylmethyl)-3-furoate (260357-07-1) → 2-(phenylsulfonylmethyl)-3-furaldehyde (260357-10-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / 20 percent aq. NaOH / ethanol

2: Et₃N / tetrahydrofuran / 1 h / -10 - -5 °C

3: NaBH₄ / tetrahydrofuran; H₂O / 3 h / 20 °C

4: 60 percent / pyridinium chlorochromate / CH₂Cl₂

With sodium hydroxide; sodium tetrahydroborate; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; ethanol; dichloromethane; water; 1: Hydrolysis / 2: Condensation / 3: Reduction / 4: Oxidation;

upstream raw materials:

2-bromomethylfuran-3-carboxylic acid methyl ester

sodium benzenesulfonate

Downstream raw materials:

2-(phenylsulfonylmethyl)-3-furoic acid

2-(phenylsulfonylmethyl)-3-furaldehyde

2-(phenylsulfonylmethyl)-3-furfuryl alcohol

Refernces