Valdecoxib 3'-SulfonaMide IMpurity

Base Information

• Chemical Name: Valdecoxib 3'-SulfonaMide IMpurity
• CAS No.: 1373038-56-2
• Molecular Formula: C₁₆H₁₄N₂O₃S
• Molecular Weight: 314.365
• Mol file: 1373038-56-2.mol

Synonyms:3-(5-methyl-4-phenylisoxazol-3-yl)benzenesulfonamide

Chemical Property of Valdecoxib 3'-SulfonaMide IMpurity

Chemical Property:

Purity/Quality:

NLT 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-(5-Methyl-4-phenylisoxazol-3-yl)benzenesulfonamide is a reagent for the large scale synthesis of Valdecoxib, a nonsteroidal anti-inflammatory drugs.

Technology Process of Valdecoxib 3'-SulfonaMide IMpurity

There total 13 articles about Valdecoxib 3'-SulfonaMide IMpurity which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.2%

C16H12ClNO3S (1373038-57-3) → 3-(5-methyl-4-phenylisoxazol-3-yl)benzenesulfonamide (1373038-56-2)

Guidance literature:

With ammonia; In dichloromethane; under 1140.08 Torr; Cooling with ice;

Reference yield:

5-methyl-3,4-diphenyl isoxazole (37928-17-9) → 3-(5-methyl-4-phenylisoxazol-3-yl)benzenesulfonamide (1373038-56-2) + valdecoxib (181695-72-7)

Guidance literature:

5-methyl-3,4-diphenyl isoxazole; With chlorosulfonic acid; In dichloromethane; at 0 ℃; Reflux;

With ammonia; In dichloromethane; water; at 25 - 35 ℃; for 1h;

DOI:10.1080/00397911.2010.528572

Reference yield:

C10H9BrN2O3S + phenylboronic acid (98-80-6) → 3-(5-methyl-4-phenylisoxazol-3-yl)benzenesulfonamide (1373038-56-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; Inert atmosphere; Reflux;

upstream raw materials:

5-methyl-3,4-diphenyl isoxazole

5-methyl-3,4-diphenyl-5-(pyrrolidin-1-yl)-4,5-dihydroisoxazole

1-(1-methyl-2-phenyl ethenyl)-pyrrolidine

C₁₆H₁₂ClNO₃S

Refernces

• 1、 -. "Directional preparation method and application of diaryl substituted isoxazole compound". . . Retrieved 2018/06/28.
• 2、 -. "Preparation method of parecoxib sodium impurity". Paragraph 0009; 0035; 0040; 0042; 0047. . Retrieved 2018/11/03.