6-methyl-2-{N-[4-N-(3-dimethylamino)propyl]carbamoyl}-3-chlorobenzo[b]thiophene anilide hydrochloride

Base Information

• Chemical Name: 6-methyl-2-{N-[4-N-(3-dimethylamino)propyl]carbamoyl}-3-chlorobenzo[b]thiophene anilide hydrochloride
• CAS No.: 1381771-40-9
• Molecular Formula: C₂₂H₂₄ClN₃O₂S*ClH
• Molecular Weight: 466.431
• Mol file: 1381771-40-9.mol

Synonyms:6-methyl-2-{N-[4-N-(3-dimethylamino)propyl]carbamoyl}-3-chlorobenzo[b]thiophene anilide hydrochloride

Chemical Property of 6-methyl-2-{N-[4-N-(3-dimethylamino)propyl]carbamoyl}-3-chlorobenzo[b]thiophene anilide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-methyl-2-{N-[4-N-(3-dimethylamino)propyl]carbamoyl}-3-chlorobenzo[b]thiophene anilide hydrochloride

There total 5 articles about 6-methyl-2-{N-[4-N-(3-dimethylamino)propyl]carbamoyl}-3-chlorobenzo[b]thiophene anilide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6-methyl-2-{N-[4-N-(3-dimethylamino)propyl]carbamoyl}-3-chlorobenzo[b]thiophene anilide (1381771-35-2) → 6-methyl-2-{N-[4-N-(3-dimethylamino)propyl]carbamoyl}-3-chlorobenzo[b]thiophene anilide hydrochloride (1381771-40-9)

Guidance literature:

With hydrogenchloride; In ethanol; at 20 ℃; for 19h;

DOI:10.1021/jm300505h

Reference yield:

N-(4-chlorocarbonylphenyl)-6-methyl-3-chlorobenzo[b]thiophene-2-carboxamide (1381771-30-7) → 6-methyl-2-{N-[4-N-(3-dimethylamino)propyl]carbamoyl}-3-chlorobenzo[b]thiophene anilide hydrochloride (1381771-40-9)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 30 h / Reflux

2: hydrogenchloride / ethanol / 19 h / 20 °C

With hydrogenchloride; In ethanol; toluene;

DOI:10.1021/jm300505h

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → 6-methyl-2-{N-[4-N-(3-dimethylamino)propyl]carbamoyl}-3-chlorobenzo[b]thiophene anilide hydrochloride (1381771-40-9)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran; toluene / 3 h / 130 °C

2: thionyl chloride / toluene / 6 h / Reflux

3: toluene / 30 h / Reflux

4: hydrogenchloride / ethanol / 19 h / 20 °C

With hydrogenchloride; thionyl chloride; triethylamine; In tetrahydrofuran; ethanol; toluene;

DOI:10.1021/jm300505h

upstream raw materials:

N-(4-chlorocarbonylphenyl)-6-methyl-3-chlorobenzo[b]thiophene-2-carboxamide

6-methyl-2-{N-[4-N-(3-dimethylamino)propyl]carbamoyl}-3-chlorobenzo[b]thiophene anilide

N-(4-carboxyphenyl)-6-methyl-3-chlorobenzo[b]thiophene-2-carboxamide

4-amino-benzoic acid

Refernces