CID 241903

Base Information Edit

Chemical Name:CID 241903
CAS No.:865-21-4
Molecular Formula:C₄₆H₅₈N₄O₉
Molecular Weight:810.988
Hs Code.:
European Community (EC) Number:212-734-0
DSSTox Substance ID:DTXSID8021430
Nikkaji Number:J10.131A
Wikipedia:Vinblastine
Wikidata:Q282629
NCI Thesaurus Code:C930
RXCUI:11198
Metabolomics Workbench ID:42905
ChEMBL ID:CHEMBL22969
Mol file:865-21-4.mol

Synonyms:cellblastin;Lemblastine;Sulfate, Vinblastine;Velban;Velbe;Vinblastin Hexal;Vinblastina Lilly;Vinblastine;Vinblastine Sulfate;Vinblastinsulfat-Gry;Vincaleukoblastine

Suppliers and Price of CID 241903

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Vinblastine
20mg
$ 320.00

DC Chemicals
Vinblastine >98%,StandardReferencesGrade
20 mg
$ 280.00

Crysdot
Vinblastine 98+%
100mg
$ 140.00

Crysdot
Vinblastine 98+%
1g
$ 650.00

AvaChem
Vinblastine
25mg
$ 49.00

AvaChem
Vinblastine
1g
$ 420.00

AvaChem
Vinblastine
100mg
$ 90.00

AvaChem
Vinblastine
50mg
$ 79.00

Arctom
Vinblastine ≥98%
20mg
$ 100.00

ApexBio Technology
vinblastine
10mg
$ 96.00

Total 111 raw suppliers

Chemical Property of CID 241903 Edit

Chemical Property:

Appearance/Colour:POWDER
Melting Point:211 - 216oC
Refractive Index:1.6000 (estimate)
Boiling Point:755.65°C (rough estimate)
PKA:5.4, 7.4(at 25℃)
PSA：154.10000
Density:1.37 g/cm³
LogP:3.93170
Storage Temp.:Sealed in dry,Store in freezer, under -20°C
Solubility.:Chloroform, Dichloromethane, Dimethyl Sulfoxide, Methanol
XLogP3:3.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:10
Exact Mass:810.42037944
Heavy Atom Count:59
Complexity:1700

Purity/Quality:

99%, ^*data from raw suppliers

Vinblastine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O
Isomeric SMILES:CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O
Recent ClinicalTrials:Doxorubicin, Vinblastine, Dacarbazine, Brentuximab Vedotin, and Nivolumab in Treating Patients With Stage I-II Hodgkin Lymphoma
Recent EU Clinical Trials:LOGGIC/FIREFLY-2: A Phase 3, Randomized, International Multicenter Trial of DAY101 Monotherapy Versus Standard of Care Chemotherapy in Patients with Pediatric Low-Grade Glioma Harboring an Activating RAF Alteration Requiring First-Line Systemic Therapy
Recent NIPH Clinical Trials:JCOG1305: Interim response adapted strategy for the advanced stage of Hodgkin Lymphoma
Description An alkaloid derived from the periwinkle, Catharanthus roseus (formerly Vinca rosea) used as an antitumor drug in the treatment of Hodgkins lymphoma and other cancers. It binds to the microtubule subunit, tubulin, at a site distinct from that of colchicine and podophyllotoxin. This binding is reversible, temperature dependent and rapid, and results in large tubulin aggregates of highly ordered structure (vinblastine paracrystals).
Physical properties Appearance: needlelike crystals were produced when recrystallized by methanol. Solubility: soluble in chloroform, acetone, and ethanol. Melting point: 211– 216?°C.?Sulfate melting point of vinblastine is 284–285?°C; hydrochloric acid melting point of vinblastine is 244–246?°C (decomposes). Specific optical rotation: +42°.
Uses Vinblastine is used for severe lymphoblastic leukemia, Hodgkin’s disease, nonHodgkin’s lymphoma, neuroblastoma, sarcoma, and other cancerous diseases. Antineoplastic. Labelled Vinblastine (V314000). Antitumor alkaloid isolated from periwinkle, Vinca rosea Linn., Apocynaceae; inhibits microtubule assembly. An antineoplastic.
Indications It was recorded in the Pharmacopoeia of the People’s Republic of China (2015), the British Pharmacopoeia (2017), the United States Pharmacopeia (40), the Japanese Pharmacopoeia (17th ed.), the European Pharmacopoeia (9th ed.), and The International Pharmacopoeia (5th ed.).Vinblastine sulfate injection is used as the first-line therapy to treat Hodgkin lymphoma, lymphocytic leukemia, testis tumor, and choriocarcinoma intravenously in clinical practice generally according to ABVD methods (Adriamycin, bleomycin, vinblastine, and dacarbazine).
Clinical Use In addition to the hematologic indications that it shares with vincristine, vinblastine sulfate has found utility in the treatment of advanced testicular carcinoma (often in combination with bleomycin), advanced mycosis fungoides, Kaposi's sarcoma, and histiocytosis X.

Technology Process of CID 241903

There total 10 articles about CID 241903 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: