α-(4-methoxyphenyl)-m,m-dimethoxycinnamic acid

Base Information

• Chemical Name: α-(4-methoxyphenyl)-m,m-dimethoxycinnamic acid
• CAS No.: 959961-16-1
• Molecular Formula: C₁₈H₁₈O₅
• Molecular Weight: 314.338
• Mol file: 959961-16-1.mol

Synonyms:α-(4-methoxyphenyl)-m,m-dimethoxycinnamic acid

Chemical Property of α-(4-methoxyphenyl)-m,m-dimethoxycinnamic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of α-(4-methoxyphenyl)-m,m-dimethoxycinnamic acid

There total 3 articles about α-(4-methoxyphenyl)-m,m-dimethoxycinnamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.4%

4-Methoxyphenylacetic acid (104-01-8) + 3,5-dimethoxybenzaldehdye (7311-34-4) → α-(4-methoxyphenyl)-m,m-dimethoxycinnamic acid (959961-16-1)

Guidance literature:

With acetic anhydride; triethylamine; at 110 ℃; for 6h; diastereoselective reaction;

DOI:10.1080/00397911.2010.538889

Reference yield:

3,5-dimethoxybenzaldehdye (7311-34-4) + sodium 2-(4-methoxyphenyl)acetate (17274-18-9) → α-(4-methoxyphenyl)-m,m-dimethoxycinnamic acid (959961-16-1)

Guidance literature:

With acetic anhydride; at 160 ℃;

Reference yield:

3,5-dimethoxybenzoyl chloride (17213-57-9) → α-(4-methoxyphenyl)-m,m-dimethoxycinnamic acid (959961-16-1)

Guidance literature:

Multi-step reaction with 2 steps

1: xylene; palladium / Hydrogenation

2: acetic acid anhydride / 160 °C

With acetic anhydride; palladium; xylene;

upstream raw materials:

3,5-dimethoxybenzaldehdye

sodium 2-(4-methoxyphenyl)acetate

4-Methoxyphenylacetic acid

3,5-dimethoxybenzoyl chloride

Downstream raw materials:

(Z)-1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)ethene

3,5,4'-trimethoxy-trans-stilbene

Refernces

• 1、 Solladié, Guy,Pasturel-Jacopé, Yacine,Maignan, Jean. "A re-investigation of resveratrol synthesis by Perkins reaction. Application to the synthesis of aryl cinnamic acids". . p. 3315 - 3321. Retrieved 2007/10/03.