2-Chloro-6-methoxypyridin-3-amine

Base Information

• Chemical Name: 2-Chloro-6-methoxypyridin-3-amine
• CAS No.: 34392-85-3
• Molecular Formula: C6H7ClN2O
• Molecular Weight: 158.587
• Hs Code.: 2933399090
• European Community (EC) Number: 251-989-2
• UNII: M9K697V59A
• DSSTox Substance ID: DTXSID60187967
• Nikkaji Number: J250.875C
• Wikidata: Q83059724
• Mol file: 34392-85-3.mol

Synonyms:34392-85-3;2-Chloro-6-methoxypyridin-3-amine;3-Amino-2-chloro-6-methoxypyridine;3-Pyridinamine, 2-chloro-6-methoxy-;2-Chloro-6-methoxypyridin-3amine;C6H7ClN2O;EINECS 251-989-2;M9K697V59A;MFCD09258809;SCHEMBL357954;UNII-M9K697V59A;C6-H7-Cl-N2-O;DTXSID60187967;2-chloro-6-methoxy-3-pyridinamine;AKOS016002970;AB49773;AM86884;CS-W021831;DS-2348;BP-21180;SY042039;3-Amino-2-chloro-6-methoxypyridine, 97%;FT-0698291;2-CHLORO-6-METHOXY-PYRIDIN-3-YLAMINE;EN300-99868;4-chloro-1-propyl-1H-imidazo[4,5-c]quinoline;A822213;J-508758

Chemical Property of 2-Chloro-6-methoxypyridin-3-amine

Chemical Property:

• Vapor Pressure: 1.45E-05mmHg at 25°C
• Melting Point: 46-50 °C
• Refractive Index: 1.592
• Boiling Point: 366.6 °C at 760 mmHg
• Flash Point: 175.5 °C
• PSA: 48.14000
• Density: 1.328 g/cm³
• LogP: 1.90700
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 158.0246905
• Heavy Atom Count: 10
• Complexity: 112

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Amino-2-chloro-6-methoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NC(=C(C=C1)N)Cl

Technology Process of 2-Chloro-6-methoxypyridin-3-amine

There total 1 articles about 2-Chloro-6-methoxypyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-chloro-6-methoxy-3-nitropyridine (38533-61-8) → 3-amino-2-chloro-6-methoxypyridine (34392-85-3)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 80 ℃; for 4h;

Reference yield: 85.0%

6-bromo-1-((3-(trifluoromethyl)phenyl)sulfonyl)-1H-indol-3-carbaldehyde + 3-amino-2-chloro-6-methoxypyridine (34392-85-3) → 6-((2-chloro-6-methoxypyridin-3-yl)amino)-1-((3-(trifluoromethyl)phenyl)sulfonyl)-1H-indol-3-carbaldehyde

Guidance literature:

With tri-tert-butyl phosphine; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; at 110 ℃; for 5h;

Reference yield: 56.0%

6-bromo-N-methyl-1-((3-(trifluoromethyl)phenyl)sulfonyl)-1H-indol-3-carboxamide + 3-amino-2-chloro-6-methoxypyridine (34392-85-3) → 6-((2-chloro-6-methoxypyridin-3-yl)amino)-N-methyl-1-((3-(trifluoromethyl)phenyl)sulfonyl)-1H-indol-3-carboxamide

Guidance literature:

With tri-tert-butyl phosphine; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; at 110 ℃; for 15h;

upstream raw materials:

2-chloro-6-methoxy-3-nitropyridine

Downstream raw materials:

2,3-dichloro-6-methoxypyridine

methyl 2-(8-(2-chloro-6-methoxypyridin-3-ylamino)octyl)-6-methoxybenzoate

6-methoxy-1,5-naphthyridin-2(1H)-one

4-chloro-6-methoxy-1,7-naphthyridine

Refernces

• 1、 Lu, Hongtao,Geng, Zhiyue,Li, Jingya,Zou, Dapeng,Wu, Yusheng,Wu, Yangjie. "Metal-Free Reduction of Aromatic Nitro Compounds to Aromatic Amines with B2pin2 in Isopropanol". supporting information. p. 2774 - 2776. Retrieved 2016/06/15.
• 2、 -. "9-AZABICYCLO [3 . 3 . 1] NONANE DERIVATIVES AS MONOAMINE REUPTAKE INHIBITORS". Page/Page column 26. . Retrieved 2010/11/26.