p-(Methoxymethyl)anisole

Base Information

• Chemical Name: p-(Methoxymethyl)anisole
• CAS No.: 1515-81-7
• Molecular Formula: C9H12 O2
• Molecular Weight: 152.193
• Hs Code.: 2909309090
• European Community (EC) Number: 216-161-7
• NSC Number: 37490
• UNII: 563PH7T92V
• DSSTox Substance ID: DTXSID0061743
• Nikkaji Number: J206.721H
• Wikidata: Q27261368
• Mol file: 1515-81-7.mol

Synonyms:1-methoxy-4-(methoxymethyl)benzene;1515-81-7;p-(Methoxymethyl)anisole;Benzene, 1-methoxy-4-(methoxymethyl)-;p-Methoxymethylanisole;4-(Methoxymethyl)anisole;(4-Methoxybenzyl) Methyl Ether;p,alpha-Dimethoxytoluene;4-methoxybenzyl methyl ether;UNII-563PH7T92V;563PH7T92V;EINECS 216-161-7;MFCD00155135;NSC 37490;NSC-37490;NSC37490;4-(methoxymethyl)-anisole;p,.alpha.-Dimethoxytoluene;SCHEMBL31270;4-METHOXYMETHYLANISOLE;SCHEMBL1151673;SCHEMBL5321146;Toluene, p,.alpha.-dimethoxy-;DTXSID0061743;SCHEMBL10205414;P-METHOXYBENZYL METHYL ETHER;METHYL-4-METHOXYBENZYL ETHER;1-methoxy-4-(methoxymethyl)-benzene;4-Methoxybenzyl alcohol, methyl ether;AKOS015995151;AS-63148;SY022059;AM20030033;CS-0150191;FT-0688409;M2305;S10552;J-523861;Q27261368

Chemical Property of p-(Methoxymethyl)anisole

Chemical Property:

• Vapor Pressure: 0.389mmHg at 25°C
• Refractive Index: 1.5130 to 1.5170
• Boiling Point: 203.8°Cat760mmHg
• Flash Point: 69.3°C
• PSA: 18.46000
• Density: 0.997g/cm³
• LogP: 1.84160
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 152.083729621
• Heavy Atom Count: 11
• Complexity: 95.7

Purity/Quality:

98%,99%, ^*data from raw suppliers

(4-Methoxybenzyl) Methyl Ether >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCC1=CC=C(C=C1)OC

Technology Process of p-(Methoxymethyl)anisole

There total 54 articles about p-(Methoxymethyl)anisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 4-Methoxybenzyl alcohol (105-13-5) → 1-methoxy-4-(methoxymethyl)benzene (1515-81-7)

Guidance literature:

With Amberlyst-15; In dichloromethane; for 2.5h; Reflux;

DOI:10.1016/j.tetlet.2012.06.084

Reference yield: 99.0%

methanol (67-56-1) + 4-methoxy-benzaldehyde (123-11-5) → 1-methoxy-4-(methoxymethyl)benzene (1515-81-7)

Guidance literature:

With Decaborane; at 20 ℃; for 4.5h;

DOI:10.1016/S0040-4039(99)01229-0

Reference yield: 96.0%

methanol (67-56-1) + 4-Methoxyphenylacetic acid (104-01-8) → 1-methoxy-4-(methoxymethyl)benzene (1515-81-7)

Guidance literature:

With piperidine; silica gel; at 0 ℃; Electrolysis;

DOI:10.1021/ja070283w

upstream raw materials:

methyl 4-methoxybenzoate

sodium methylate

p-methoxybenzyl chloride

paracetaldehyde

Downstream raw materials:

methyl 4-methoxybenzoate

4-methoxy-benzaldehyde

4-Methoxybenzyl alcohol

(2S,3R,4R,6R,8R,9S,10R,11R)-11-[(benzyloxy)methoxy]-1,4-bis[(tert-butyldimethylsilyl)oxy]-9-hydroxy-3-[(4-methoxybenzyl)oxy]-2,4,6,8,10-pentamethyltridecan-7-one

Refernces

• 1、 Carlet, Federica,Bertarini, Greta,Broggini, Gianluigi,Pradal, Alexandre,Poli, Giovanni. "Oxoammonium-Mediated Allylsilane–Ether Coupling Reaction". supporting information. p. 2162 - 2168. Retrieved 2021/04/02.
• 2、 Tong, Xinli,Guo, Pengfei,Liao, Shengyun,Xue, Song,Zhang, Haigang. "Nickel-catalyzed intelligent reductive transformation of the aldehyde group using hydrogen". . p. 5828 - 5840. Retrieved 2019/11/11.