Technology Process of 3-Benzofuran-4-yl-2-(4-methoxy-benzoyl)-4-nitro-butyric acid ethyl ester
There total 5 articles about 3-Benzofuran-4-yl-2-(4-methoxy-benzoyl)-4-nitro-butyric acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF
2: 1.) polyphosphoric acid, 2.) t-BuLi / 1.) benzene, reflux, 2.) Et2O, -78 deg C, 3.) Et2O
3: 50percent aq. NaOH / 15 °C
4: DBU / propan-2-ol; tetrahydrofuran
With
sodium hydroxide; PPA; tert.-butyl lithium; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran; isopropyl alcohol;
DOI:10.1021/jm960077r
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 50percent aq. NaOH / 15 °C
2: DBU / propan-2-ol; tetrahydrofuran
With
sodium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran; isopropyl alcohol;
DOI:10.1021/jm960077r
- Guidance literature:
-
Multi-step reaction with 2 steps
1: NaH
2: DBU / propan-2-ol; tetrahydrofuran
With
sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran; isopropyl alcohol;
DOI:10.1021/jm960077r