2,4-Difluoroiodobenzene

Base Information

• Chemical Name: 2,4-Difluoroiodobenzene
• CAS No.: 2265-93-2
• Molecular Formula: C6H3F2I
• Molecular Weight: 239.991
• Hs Code.: 29039990
• Mol file: 2265-93-2.mol

Synonyms:1-Iodo-2,4-difluorobenzene;2,4-Difluoro-1-iodobenzene;NSC 68264;

Chemical Property of 2,4-Difluoroiodobenzene

Chemical Property:

• Appearance/Colour: clear light yellow to slightly brown liquid
• Vapor Pressure: 1.2mmHg at 25°C
• Refractive Index: n20/D 1.557(lit.)
• Boiling Point: 180.6 °C at 760 mmHg
• Flash Point: 67.8 °C
• PSA: 0.00000
• Density: 2.001 g/cm³
• LogP: 2.56940
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive.: Light Sensitive
• Water Solubility.: INSOLUBLE

Purity/Quality:

99% ^*data from raw suppliers

2,4-Difluoroiodobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,4-Difluoroiodobenzene may be used in the preparation of:1,2,4-tris(1H-pyrazolyl)benzene, by reaction with pyrazole catalyzed by Cu2O, salicylaldoxime and Cs2CO3 in acetonitrile3-(2,4-difluorophenyl)-2-propyn-1-olN-(2-((2,4-difluorophenyl)thio)-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)methanesulfonamide.

Technology Process of 2,4-Difluoroiodobenzene

There total 7 articles about 2,4-Difluoroiodobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2,4-difluorophenylboronic acid (144025-03-6) → 2,4-difluoro-1-iodobenzene (2265-93-2)

Guidance literature:

With iodine; potassium carbonate; In acetonitrile; at 80 ℃; for 14h; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1055/s-0033-1340871

Reference yield: 48.0%

2,6-difluoroiodobenzene (13697-89-7) → 2,4-difluoro-1-iodobenzene (2265-93-2)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -75 ℃;

DOI:10.1002/1099-0690(200210)2002:19<3351::AID-EJOC3351>3.0.CO;2-I

Reference yield:

2,6-difluoroiodobenzene (13697-89-7) + acetonitrile (75-05-8,26809-02-9) → iodoacetonitrile (624-75-9) + 1,3-Difluorobenzene (372-18-9) + 2,4-difluoro-1-iodobenzene (2265-93-2)

Guidance literature:

for 24h; Product distribution; Irradiation;

DOI:10.1246/bcsj.70.1875

upstream raw materials:

2,4-difluorophenylamine

2,6-difluoroiodobenzene

acetonitrile

1,3-Difluorobenzene

Downstream raw materials:

2,4-difluorofluorenone

iodoacetonitrile

1,3-Difluorobenzene

2-tert-Butoxycarbonylamino-5-(2,4-difluoro-phenyl)-pent-4-ynoic acid methyl ester

Refernces

• 1、 -. "Method for producing tetrakis ( fluoroaryl) borate-magnesium compound". . . Retrieved 2008/06/13.
• 2、 Song, Yong-Qi,Yuzuri, Tomoaki,Suezawa, Hiroko,Sakakibara, Kazuhisa,Hirota, Minoru,Nakada, Masahiro. "The Photolyses of 2,6- and 2,4-Difluorohalobenzenes". . p. 1875 - 1878. Retrieved 2007/10/03.