2,2,2-trifluoro-1-phenylethyl 2-naphthoate

Base Information

• Chemical Name: 2,2,2-trifluoro-1-phenylethyl 2-naphthoate
• CAS No.: 1228172-17-5
• Molecular Formula: C₁₉H₁₃F₃O₂
• Molecular Weight: 330.306
• Mol file: 1228172-17-5.mol

Synonyms:2,2,2-trifluoro-1-phenylethyl 2-naphthoate

Chemical Property of 2,2,2-trifluoro-1-phenylethyl 2-naphthoate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2,2,2-trifluoro-1-phenylethyl 2-naphthoate

There total 2 articles about 2,2,2-trifluoro-1-phenylethyl 2-naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,2,2-Trifluoroacetophenone (434-45-7) + β-naphthaldehyde (66-99-9) → 2,2,2-trifluoro-1-phenylethyl 2-naphthoate (1228172-17-5)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; tris(pentafluorophenyl)borate; 1,2-bis-(dicyclohexylphosphino)ethane; In tetrahydrofuran; at 60 ℃; for 24h; Reagent/catalyst; Glovebox; Inert atmosphere;

DOI:10.1021/ja511730k

Reference yield: 72.0%

2,2,2-Trifluoroacetophenone (434-45-7) + phenyl thiobenzoate (884-09-3) + β-naphthaldehyde (66-99-9) → 2,2,2-trifluoro-1-phenylethyl 2-naphthoate (1228172-17-5) + 1-benzoyloxy-1-phenyl-2,2,2-trifluoroethane (17659-27-7,124717-22-2)

Guidance literature:

With 3-trifluoromethyl-thiophenol; phenylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 65 ℃; for 24h; Inert atmosphere;

DOI:10.1002/anie.200907167

upstream raw materials:

2,2,2-Trifluoroacetophenone

phenyl thiobenzoate

β-naphthaldehyde

Refernces

• 1、 Curran, Simon P.,Connon, Stephen J.. "Selenide ions as catalysts for homo- and crossed-Tishchenko reactions of expanded scope". supporting information; experimental part. p. 1074 - 1077. Retrieved 2012/03/27.