Pseudouridine 5'-phosphate

Base Information

• Chemical Name: Pseudouridine 5'-phosphate
• CAS No.: 1157-60-4
• Molecular Formula: C₉H₁₃N₂O₉P
• Molecular Weight: 324.184
• Nikkaji Number: J2.731.765K
• Wikidata: Q27102833
• Metabolomics Workbench ID: 37698
• Mol file: 1157-60-4.mol

Synonyms:pseudouridylic acid

Chemical Property of Pseudouridine 5'-phosphate

Chemical Property:

• Vapor Pressure: 2.7E-22mmHg at 25°C
• Boiling Point: 728.8°C at 760 mmHg
• Flash Point: 394.6°C
• PSA: 191.98000
• Density: 1.833g/cm³
• LogP: -2.66580
• XLogP3: -4.5
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 4
• Exact Mass: 324.03586699
• Heavy Atom Count: 21
• Complexity: 529

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=O)NC(=O)N1)C2C(C(C(O2)COP(=O)(O)O)O)O
• Isomeric SMILES: C1=C(C(=O)NC(=O)N1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O

Technology Process of Pseudouridine 5'-phosphate

There total 2 articles about Pseudouridine 5'-phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

D-ribose 5-phosphate (93-87-8) + uracil (66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6) → pseudouridine 5'-monophosphate (1157-60-4)

Guidance literature:

With Escherichia coli ΨMP glycosidase; manganese(ll) chloride; In aq. buffer; at 25 ℃; for 1h; pH=7.1; Reagent/catalyst; Kinetics; Catalytic behavior; Enzymatic reaction;

DOI:10.1021/bi3006829

Reference yield:

→ pseudouridine 5'-monophosphate (1157-60-4)

Guidance literature:

aus Pseudouridin durch Phosphorilierung;

DOI:10.1016/0005-2787(71)90573-9

upstream raw materials:

D-ribose 5-phosphate

uracil

Refernces

• 1、 Schweizer,Thedford,Slama. "Synthesis and conformational properties of diribonucleoside monophosphates containing modified nucleosides as found in transfer RNA.". . p. 217 - 226. Retrieved 1971.