methyl 2-(3,5-difluorophenyl)acetate

Base Information

• Chemical Name: methyl 2-(3,5-difluorophenyl)acetate
• CAS No.: 210530-70-4
• Molecular Formula: C₉H₈F₂O₂
• Molecular Weight: 186.158
• Hs Code.: 2916399090
• Mol file: 210530-70-4.mol

Synonyms:methyl 2-(3,5-difluorophenyl)acetate

Chemical Property of methyl 2-(3,5-difluorophenyl)acetate

Chemical Property:

• Boiling Point: 196.6±25.0 °C(Predicted)
• Density: 1.235±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

3,5-Difluorobenzeneaceticacidmethylester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (3,5-Difluoro-phenyl)acetic Acid Methyl Ester was studied for its usefulness as an antibiotic. It is also used as a reactant in the synthesis of diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus.

Technology Process of methyl 2-(3,5-difluorophenyl)acetate

There total 3 articles about methyl 2-(3,5-difluorophenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 3,5-difluorophenyl acetic acid (105184-38-1) → methyl 2-(3,5-difluorophenyl)acetate (210530-70-4)

Guidance literature:

With thionyl chloride; for 4h; Reflux;

Reference yield: 100.0%

3,5-difluorophenyl acetic acid (105184-38-1) + methyl iodide (74-88-4) → methyl 2-(3,5-difluorophenyl)acetate (210530-70-4)

Guidance literature:

With potassium carbonate; In acetone; at 60 ℃;

DOI:10.1002/adsc.201901343

Reference yield:

3,5-difluorophenyl acetic acid (105184-38-1) + acetyl chloride (75-36-5) → methyl 2-(3,5-difluorophenyl)acetate (210530-70-4)

Guidance literature:

In methanol; at 0 - 20 ℃;

upstream raw materials:

methanol

3,5-difluorophenyl acetic acid

acetyl chloride

methyl iodide

Downstream raw materials:

2-(3,5-difluorophenyl)acetaldehyde

methyl 2-(3,5-difluorophenyl)-3-dimethylamino-2-propenoate

Methyl {1-[bis(4-chlorophenyl)methyl]-3-hydroxyazetidin-3-yl}(3,5-difluorophenyl) acetate

Methyl {1-[bis(4-chlorophenyl)methyl]azetidin-3-ylidene}(3,5-difluorophenyl)acetate

Refernces

• 1、 Stivanin, Mateus L.,Fernandes, Alessandra A. G.,da Silva, Amanda F.,Okada, Celso Y.,Jurberg, Igor D.. "Blue Light-Promoted N?H Insertion of Carbazoles, Pyrazoles and 1,2,3-Triazoles into Aryldiazoacetates". supporting information. p. 1106 - 1111. Retrieved 2020/01/25.
• 2、 -. "PYRIDINEAMINE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS". Page/Page column 96-97. . Retrieved 2016/12/22.