Technology Process of (1S)-1-[3,4-dimethoxy-2-(S)-p-tolylsulfinyl]benzyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline
There total 10 articles about (1S)-1-[3,4-dimethoxy-2-(S)-p-tolylsulfinyl]benzyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetyl chloride / 4 h / Inert atmosphere; Reflux
1.2: 1 h / 90 - 100 °C / Inert atmosphere
2.1: titanium(IV) tetraethanolate / dichloromethane / 4 h / Reflux; Inert atmosphere
3.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
3.2: -78 - 20 °C / Inert atmosphere
4.1: trifluoroacetic acid / methanol / 3 h / 0 °C / Inert atmosphere
With
titanium(IV) tetraethanolate; acetyl chloride; trifluoroacetic acid; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1016/j.tet.2011.11.046
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: titanium(IV) tetraethanolate / dichloromethane / 4 h / Reflux; Inert atmosphere
2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
3.1: trifluoroacetic acid / methanol / 3 h / 0 °C / Inert atmosphere
With
titanium(IV) tetraethanolate; trifluoroacetic acid; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1016/j.tet.2011.11.046