2-(2-nitropropyl)-6-methoxybenzoic acid

Base Information

• Chemical Name: 2-(2-nitropropyl)-6-methoxybenzoic acid
• CAS No.: 115912-96-4
• Molecular Formula: C₁₁H₁₃NO₅
• Molecular Weight: 239.228
• Mol file: 115912-96-4.mol

Synonyms:2-(2-nitropropyl)-6-methoxybenzoic acid

Chemical Property of 2-(2-nitropropyl)-6-methoxybenzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(2-nitropropyl)-6-methoxybenzoic acid

There total 2 articles about 2-(2-nitropropyl)-6-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-(1-nitroethyl)-7-methoxy-1(3H)-isobenzofuranone (56512-99-3) → 2-(2-nitropropyl)-6-methoxybenzoic acid (115912-96-4)

Guidance literature:

With sodium tetrahydroborate; In dimethyl sulfoxide; for 1h; Ambient temperature;

DOI:10.1021/jo00255a006

Reference yield:

3-hydroxy-7-methoxy-3H-isobenzofuran-1-one (73274-87-0,73713-38-9) → 2-(2-nitropropyl)-6-methoxybenzoic acid (115912-96-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / triethylamine / dimethylsulfoxide / 48 h / Ambient temperature

2: 95 percent / NaBH₄ / dimethylsulfoxide / 1 h / Ambient temperature

With sodium tetrahydroborate; triethylamine; In dimethyl sulfoxide;

DOI:10.1021/jo00255a006

Reference yield:

2-(2-nitropropyl)-6-methoxybenzoic acid (115912-96-4) → 8-methoxy-3-methyl-1H-isochromen-1-one (830-54-6)

Guidance literature:

With hydrogenchloride; perchloric acid; titanium(III) chloride; ammonium acetate; sodium methylate; acetic anhydride; Yield given. Multistep reaction; 1.) THF, H₂O, RT, 1.5 h, nitrogen atmosphere, 2.) EtOAc, RT, 1 h;

DOI:10.1021/jo00255a006

upstream raw materials:

3-(1-nitroethyl)-7-methoxy-1(3H)-isobenzofuranone

3-hydroxy-7-methoxy-3H-isobenzofuran-1-one

Downstream raw materials:

8-methoxy-3-methyl-1H-isochromen-1-one

Refernces