dibenzyl (R)-1-(1-methyl-2-oxopropyl)hydrazine-1,2-dicarboxylate

Base Information

• Chemical Name: dibenzyl (R)-1-(1-methyl-2-oxopropyl)hydrazine-1,2-dicarboxylate
• CAS No.: 1112997-64-4
• Molecular Formula: C₂₀H₂₂N₂O₅
• Molecular Weight: 370.405
• Mol file: 1112997-64-4.mol

Synonyms:dibenzyl (R)-1-(1-methyl-2-oxopropyl)hydrazine-1,2-dicarboxylate

Chemical Property of dibenzyl (R)-1-(1-methyl-2-oxopropyl)hydrazine-1,2-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dibenzyl (R)-1-(1-methyl-2-oxopropyl)hydrazine-1,2-dicarboxylate

There total 3 articles about dibenzyl (R)-1-(1-methyl-2-oxopropyl)hydrazine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

dibenzyl azodicarboxylate (2449-05-0) + butanone (78-93-3) → dibenzyl (R)-1-(1-methyl-2-oxopropyl)hydrazine-1,2-dicarboxylate (1112997-64-4)

Guidance literature:

With (2S,4R)-4-(tert-butoxy)pyrrolidine-2-carboxylic acid; In dichloromethane; at 20 ℃; for 40h; optical yield given as %ee; enantioselective reaction;

DOI:10.2174/157017809788681293

Reference yield:

2,2-dimethoxybutane (3453-99-4) + dibenzyl azodicarboxylate (2449-05-0) → dibenzyl (R)-1-(1-methyl-2-oxopropyl)hydrazine-1,2-dicarboxylate (1112997-64-4) + dibenzyl (S)-1-(1-methyl-2-oxopropyl)hydrazine-1,2-dicarboxylate

Guidance literature:

With chloroacetic acid; trifluoroacetic acid; 5-[(2S)-pyrrolidine-2-yl]-1H-tetrazole; In dichloromethane; water; at 4 ℃; for 48h; Overall yield = 33%;

DOI:10.1016/j.tetlet.2014.02.097

Reference yield:

dibenzyl azodicarboxylate (2449-05-0) + butanone (78-93-3) → dibenzyl (R)-1-(1-methyl-2-oxopropyl)hydrazine-1,2-dicarboxylate (1112997-64-4) + dibenzyl (S)-1-(1-methyl-2-oxopropyl)hydrazine-1,2-dicarboxylate

Guidance literature:

With trans-3-tert-butoxy-L-proline; In dichloromethane; at 20 ℃; for 40h; optical yield given as %ee; enantioselective reaction;

DOI:10.2174/157017809788681293

upstream raw materials:

dibenzyl azodicarboxylate

butanone

2,2-dimethoxybutane

Refernces

• 1、 Beattie, Christopher,North, Michael,Villuendas, Pedro. "Proline-catalysed amination reactions in cyclic carbonate solvents". experimental part. p. 3420 - 3432. Retrieved 2011/06/22.