Technology Process of 3,3,3-trifluoro-1-phenyl-1-(3-pyridyl)propene
There total 3 articles about 3,3,3-trifluoro-1-phenyl-1-(3-pyridyl)propene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate;
In
dimethyl sulfoxide;
at 20 ℃;
for 2h;
Overall yield = 78 %; Overall yield = 48 mg; stereoselective reaction;
Schlenk technique;
Inert atmosphere;
Irradiation;
DOI:10.3762/bjoc.10.108
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C / Schlenk technique; Inert atmosphere
1.2: 12 h / 20 °C / Schlenk technique; Inert atmosphere
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,2-dichloro-ethane / 18 h / 90 °C / Schlenk technique; Inert atmosphere
With
potassium tert-butylate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1002/adsc.201901105
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate / dimethyl sulfoxide / 2 h / 20 °C / Schlenk technique; Inert atmosphere; Irradiation
With
tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; sodium hexamethyldisilazane;
In
tetrahydrofuran; dimethyl sulfoxide;
1.1: |Wittig Olefination / 1.2: |Wittig Olefination;
DOI:10.3762/bjoc.10.108