Gonadorelin acetate

Base Information

• Chemical Name: Gonadorelin acetate
• CAS No.: 34973-08-5
• Deprecated CAS: 66036-44-0
• Molecular Formula: C55H75N17O13^.C2H4O2
• Molecular Weight: 1227.34
• European Community (EC) Number: 251-553-1,636-116-9,683-628-3
• DSSTox Substance ID: DTXSID30198161
• Wikipedia: Gonadorelin
• NCI Thesaurus Code: C65814
• ChEMBL ID: CHEMBL1200511
• Mol file: 34973-08-5.mol

Synonyms:Cystorelin;Dirigestran;Factrel;FSH Releasing Hormone;FSH-Releasing Hormone;Gn-RH;GnRH;Gonadoliberin;Gonadorelin;Gonadorelin Acetate;Gonadorelin Hydrochloride;Gonadotropin Releasing Hormone;Gonadotropin-Releasing Hormone;Kryptocur;LFRH;LH FSH Releasing Hormone;LH Releasing Hormone;LH-FSH Releasing Hormone;LH-Releasing Hormone;LH-RH;LHFSH Releasing Hormone;LHFSHRH;LHRH;Luliberin;Luteinizing Hormone Releasing Hormone;Luteinizing Hormone-Releasing Hormone;Releasing Hormone, LHFSH

Chemical Property of Gonadorelin acetate

Chemical Property:

• PSA: 509.43000
• LogP: 1.19830
• Storage Temp.: Hygroscopic, Refrigerator, Under inert atmosphere
• Solubility.: Methanol (Slightly), Water (Slightly)
• Hydrogen Bond Donor Count: 17
• Hydrogen Bond Acceptor Count: 17
• Rotatable Bond Count: 31
• Exact Mass: 1241.59415488
• Heavy Atom Count: 89
• Complexity: 2420

Purity/Quality:

98% ^*data from raw suppliers

GonadorelinAcetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NCC(=O)N)NC(=O)CNC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CN=CN5)NC(=O)C6CCC(=O)N6.CC(=O)O
• Isomeric SMILES: CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N)NC(=O)CNC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6.CC(=O)O
• Recent ClinicalTrials: Hormonal Mechanisms of Sleep Restriction - Axis Study
• Recent EU Clinical Trials: Optimizing the fertility potential of bilateral cryptorchidism by treatment
• Description: Gonadorelin Acetate is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis.Gonadorelin, also known as GnRH or LHRH, is produced by neuroendocrine cells within the hypothalamus. The hormone is secreted pulsatilely. Gonadorelin induces the release of LH and FSH from the anterior pituitary.After a transient increase, continuous administration of gonadorelin results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis. Gonadorelin is a tropic hormone and agonist of the gonadotropin-releasing hormone receptor (GNRHR; Ki = 13 nM in CHO cells expressing the human receptor). It stimulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release from rat anterior pituitary cultures when administered at a dose of 0.1 μg. It also stimulates LH release from bovine anterior pituitary cultures at a concentration of 1 μM. In vivo, gonadorelin induces ovulation in rats pretreated with fluphenazine (; ED50 = 610.3 ng/kg). Formulations containing gonadorelin have been used as diagnostic agents to assess pituitary gland function.
• Uses: Gonadorelin Acetate is used in various agricultural and biological studies. It was used in the study of ovulation synchronization in dairy cows. Gonad-stimulating principle.
• Indications: Gonadorelin is a synthetic decapeptide with a structure identical with the natural Gonadotrophin Releasing Hormone (Gn-RH) in mammalian species.Gonadorelin is recommended for the treatment of reproductive disorders associated with ovarian cysts and for improvement of fertility in cows and for the induction of ovulation in rabbits. The mechanism of action underlying the therapeutic use is the stimulation of the release from and also the synthesis of LH and FSH in the anterior pituitary gland.