C₄₂H₆₆O₆SiNCOCF₃

Base Information Edit

Chemical Name:C₄₂H₆₆O₆SiNCOCF₃
CAS No.:935872-55-2
Molecular Formula:C₄₄H₆₆F₃NO₇Si
Molecular Weight:806.091
Hs Code.:
Mol file:935872-55-2.mol

C<sub>42</sub>H<sub>66</sub>O<sub>6</sub>SiNCOCF<sub>3</sub>

Synonyms:C₄₂H₆₆O₆SiNCOCF₃

Suppliers and Price of C₄₂H₆₆O₆SiNCOCF₃

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of C₄₂H₆₆O₆SiNCOCF₃ Edit

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of C₄₂H₆₆O₆SiNCOCF₃

There total 37 articles about C₄₂H₆₆O₆SiNCOCF₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 935872-13-2
(2S,4E,6E,8S,9S,11R,13S,15S,16S)-16-(tert-butyldimethylsilyloxy)-2-{(1R,2R)-2-[(4-methoxybenzyloxy)methyl]cyclopentyl}-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-diene-7-carboxamide

: 76-05-1
trifluoroacetic acid

: 935872-55-2
C₄₂H₆₆O₆SiNCOCF₃

: 714974-06-8
(2S,4E,6Z,8S,9S,11R,13S,15S,16S)-16-(tert-butyldimethylsilyloxy)-8-hydroxy-2-{(1R,2R)-2-[(4-methoxybenzyloxy)methyl]cyclopentyl}-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-diene-7-carbonitrile

Guidance literature:: With 2-chloro-1,3-dimethylimidazolinium chloride; In dichloromethane; at 20 ℃; for 1.5h;
DOI:10.1021/jo062089i

Reference yield:

: 57287-24-8
(1R,2R)-1,2-(dihydroxymethyl)cyclopentane

: 935872-55-2
C₄₂H₆₆O₆SiNCOCF₃

Guidance literature:: Multi-step reaction with 18 steps

1.1: NaH / dimethylformamide / -20 - 20 °C

2.1: 6.24 g / Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / 20 °C

3.1: 54 percent / tetrahydrofuran / 0.5 h / -78 °C

4.1: 99 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

5.1: H₂O; NMO; OsO₄ / acetone / 4 h / 20 °C

6.1: 533 mg / NaIO₄; H₂O / methanol / 2 h / 0 °C

7.1: 73 percent / benzene / 48 h / 80 °C

8.1: 84 percent / benzene / 39 h / 70 °C

9.1: 96 percent / HF*pyridine; pyridine / tetrahydrofuran / 228 h / 20 °C

10.1: 452 mg / Et₃N; DMAP / benzene / 2 h / 20 °C

11.1: 96 percent / PPTS / ethanol / 16 h / 50 °C

12.1: TPAP; NMO; 4 Angstroem molecular sieves / CH₂Cl₂ / 1.5 h / 20 °C

13.1: SmI₂ / tetrahydrofuran / 1 h / -78 °C

13.2: Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / 20 °C

14.1: DMAP / pentane / 168 h / 20 °C

14.2: 31.2 mg / NaBH₄; CeCl₃*7H₂O / methanol / 0.5 h / 0 °C

15.1: 85 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

16.1: 85 percent / NaBH₄ / Pd(PPh₃)4 / methanol / 0.5 h / 0 °C

17.1: 69 percent / NH₃; Et₃N; BOP / dioxane; tetrahydrofuran / 48 h / 23 °C

18.1: 31 percent / 2-chloro-1,3-dimethylimidazolinium chloride / CH₂Cl₂ / 1.5 h / 20 °C

With pyridine; 2,6-dimethylpyridine; dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; samarium diiodide; tetrapropylammonium perruthennate; 4 A molecular sieve; ammonia; water; pyridinium p-toluenesulfonate; 2-chloro-1,3-dimethylimidazolinium chloride; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; Dess-Martin periodane; pyridine hydrogenfluoride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; pentane; benzene; 2.1: Dess-Martin oxidation / 7.1: Wittig reaction / 8.1: Wittig reaction / 13.2: Dess-Martin oxidation;
DOI:10.1021/jo062089i

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 935872-55-2
C₄₂H₆₆O₆SiNCOCF₃

Guidance literature:: Multi-step reaction with 18 steps

1.1: NaH / dimethylformamide / -20 - 20 °C

2.1: 6.24 g / Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / 20 °C

3.1: 54 percent / tetrahydrofuran / 0.5 h / -78 °C

4.1: 99 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

5.1: H₂O; NMO; OsO₄ / acetone / 4 h / 20 °C

6.1: 533 mg / NaIO₄; H₂O / methanol / 2 h / 0 °C

7.1: 73 percent / benzene / 48 h / 80 °C

8.1: 84 percent / benzene / 39 h / 70 °C

9.1: 96 percent / HF*pyridine; pyridine / tetrahydrofuran / 228 h / 20 °C

10.1: 452 mg / Et₃N; DMAP / benzene / 2 h / 20 °C

11.1: 96 percent / PPTS / ethanol / 16 h / 50 °C

12.1: TPAP; NMO; 4 Angstroem molecular sieves / CH₂Cl₂ / 1.5 h / 20 °C

13.1: SmI₂ / tetrahydrofuran / 1 h / -78 °C

13.2: Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / 20 °C

14.1: DMAP / pentane / 168 h / 20 °C

14.2: 31.2 mg / NaBH₄; CeCl₃*7H₂O / methanol / 0.5 h / 0 °C

15.1: 85 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

16.1: 85 percent / NaBH₄ / Pd(PPh₃)4 / methanol / 0.5 h / 0 °C

17.1: 69 percent / NH₃; Et₃N; BOP / dioxane; tetrahydrofuran / 48 h / 23 °C

18.1: 31 percent / 2-chloro-1,3-dimethylimidazolinium chloride / CH₂Cl₂ / 1.5 h / 20 °C

With pyridine; 2,6-dimethylpyridine; dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; samarium diiodide; tetrapropylammonium perruthennate; 4 A molecular sieve; ammonia; water; pyridinium p-toluenesulfonate; 2-chloro-1,3-dimethylimidazolinium chloride; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; Dess-Martin periodane; pyridine hydrogenfluoride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; pentane; benzene; 2.1: Dess-Martin oxidation / 7.1: Wittig reaction / 8.1: Wittig reaction / 13.2: Dess-Martin oxidation;
DOI:10.1021/jo062089i