benzyl N-maleimidyl carbonate

Base Information

• Chemical Name: benzyl N-maleimidyl carbonate
• CAS No.: 58936-19-9
• Molecular Formula: C₁₂H₉NO₅
• Molecular Weight: 247.207
• Mol file: 58936-19-9.mol

Synonyms:benzyl N-maleimidyl carbonate

Chemical Property of benzyl N-maleimidyl carbonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of benzyl N-maleimidyl carbonate

There total 2 articles about benzyl N-maleimidyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

Carbonic acid benzyl ester 3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl ester (58936-18-8) → benzyl N-maleimidyl carbonate (58936-19-9)

Guidance literature:

With 3-tert-butylbenzene-1,2-diol; In nitrobenzene; at 155 - 160 ℃; for 0.5h; under 100 Torr;

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → benzyl N-maleimidyl carbonate (58936-19-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / triethylamine / dimethylformamide / 2 h / Ambient temperature

2: 83 percent / t-butylcatechol / nitrobenzene / 0.5 h / 155 - 160 °C / 100 Torr

With 3-tert-butylbenzene-1,2-diol; triethylamine; In nitrobenzene; N,N-dimethyl-formamide;

Reference yield: 44.0%

benzyl N-maleimidyl carbonate (58936-19-9) → N-hydroxymaleimide (4814-74-8)

Guidance literature:

With trifluoroacetic acid; for 50h; Ambient temperature;

upstream raw materials:

Carbonic acid benzyl ester 3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl ester

benzyl chloroformate

Downstream raw materials:

N-hydroxymaleimide

Refernces