2,2-bis(methylthio)vinyl 4-phenoxyphenyl ketone

Base Information

• Chemical Name: 2,2-bis(methylthio)vinyl 4-phenoxyphenyl ketone
• CAS No.: 56944-73-1
• Molecular Formula: C₁₇H₁₆O₂S₂
• Molecular Weight: 316.445
• Mol file: 56944-73-1.mol

Synonyms:2,2-bis(methylthio)vinyl 4-phenoxyphenyl ketone

Chemical Property of 2,2-bis(methylthio)vinyl 4-phenoxyphenyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-bis(methylthio)vinyl 4-phenoxyphenyl ketone

There total 2 articles about 2,2-bis(methylthio)vinyl 4-phenoxyphenyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.8%

carbon disulfide (75-15-0,12122-00-8) + 4-phenoxyacetophenone (5031-78-7) + methyl iodide (74-88-4) → 2,2-bis(methylthio)vinyl 4-phenoxyphenyl ketone (56944-73-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl acetamide; benzene; at 25 - 30 ℃; for 2h;

DOI:10.1248/cpb.34.701

Reference yield:

carbon disulfide (75-15-0,12122-00-8) + 4-phenoxyacetophenone (5031-78-7) + dimethyl sulfate (77-78-1) → 2,2-bis(methylthio)vinyl 4-phenoxyphenyl ketone (56944-73-1)

Guidance literature:

4-phenoxyacetophenone; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.25h; Inert atmosphere;

carbon disulfide; In tetrahydrofuran; at 0 ℃; for 4h; Inert atmosphere;

dimethyl sulfate; In tetrahydrofuran; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1039/c4ob01300j

Reference yield: 84.0%

ethanol (64-17-5) + 2,2-bis(methylthio)vinyl 4-phenoxyphenyl ketone (56944-73-1) → ethyl 3-oxo-3-(4-phenoxyphenyl)propanoate (59447-12-0)

Guidance literature:

With sulfuric acid; for 3h; Heating;

DOI:10.1248/cpb.34.701

upstream raw materials:

carbon disulfide

4-phenoxyacetophenone

methyl iodide

dimethyl sulfate

Downstream raw materials:

ethyl 3-oxo-3-(4-phenoxyphenyl)propanoate

ethyl 2-acetylthio-2-(4-phenoxybenzoyl)acetate

Refernces

• 1、 Yang, Xiaobing,Hu, Fangzhong,Di, Hongjing,Cheng, Xinxin,Li, Dan,Kan, Xiaoli,Zou, Xiaomao,Zhang, Qichun. "A convenient base-mediated synthesis of 3-aryol-4-methyl (or benzyl)-2-methylthio furans from α-oxo ketene dithioacetals and propargyl alcohols via domino coupling/annulations". supporting information. p. 8947 - 8951. Retrieved 2014/12/11.