(17β)-17-(3-tert-butylbenzyl)-estra-1(10),2,4-triene-3,17-diol

Base Information

• Chemical Name: (17β)-17-(3-tert-butylbenzyl)-estra-1(10),2,4-triene-3,17-diol
• CAS No.: 1215115-65-3
• Molecular Formula: C₂₉H₃₈O₂
• Molecular Weight: 418.62
• Mol file: 1215115-65-3.mol

Synonyms:(17β)-17-(3-tert-butylbenzyl)-estra-1(10),2,4-triene-3,17-diol

Chemical Property of (17β)-17-(3-tert-butylbenzyl)-estra-1(10),2,4-triene-3,17-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (17β)-17-(3-tert-butylbenzyl)-estra-1(10),2,4-triene-3,17-diol

There total 6 articles about (17β)-17-(3-tert-butylbenzyl)-estra-1(10),2,4-triene-3,17-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C35H52O2Si (1334336-44-5) → (17β)-17-(3-tert-butylbenzyl)-estra-1(10),2,4-triene-3,17-diol (1215115-65-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.583333h; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.06.027

Reference yield:

3-tert-butylphenyol (585-34-2) → (17β)-17-(3-tert-butylbenzyl)-estra-1(10),2,4-triene-3,17-diol (1215115-65-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C

2.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 20 - 90 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 20 °C

5.1: magnesium / diethyl ether / 2 h / 20 °C / Inert atmosphere

5.2: 20 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.58 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; lithium aluminium tetrahydride; carbon tetrabromide; 1,3-bis-(diphenylphosphino)propane; tetrabutyl ammonium fluoride; palladium diacetate; magnesium; triethylamine; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 5.1: Grignard reaction / 5.2: Grignard reaction;

DOI:10.1016/j.ejmech.2011.06.027

Reference yield:

3-tert-butylbenzyl bromide (102405-32-3) → (17β)-17-(3-tert-butylbenzyl)-estra-1(10),2,4-triene-3,17-diol (1215115-65-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: magnesium / diethyl ether / 2 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.58 h / 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; magnesium; In tetrahydrofuran; diethyl ether; 1.1: Grignard reaction / 1.2: Grignard reaction;

DOI:10.1016/j.ejmech.2011.06.027

upstream raw materials:

C₃₅H₅₂O₂Si

3-tert-butylphenyol

3-tert-butylbenzyl alcohol

methyl 3-(tert-butyl)benzoate

Refernces