Latrunculin A Methyl Ketal

Base Information

• Chemical Name: Latrunculin A Methyl Ketal
• CAS No.: 76343-89-0
• Molecular Formula: C₂₃H₃₃NO₅S
• Molecular Weight: 435.585
• Mol file: 76343-89-0.mol

Synonyms:Latrunculin A Methyl Ketal

Chemical Property of Latrunculin A Methyl Ketal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Latrunculin A Methyl Ketal

There total 4 articles about Latrunculin A Methyl Ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

methanol (67-56-1) + latrunculin A (76343-93-6) → Latrunculin A Methyl Ketal (76343-89-0)

Guidance literature:

With boron trifluoride diethyl etherate; at 20 ℃; for 12h;

DOI:10.1002/cmdc.200900430

Reference yield: 4.0%

methanol (67-56-1) + Latrunculin A (76343-93-6) → 17-Methoxy-Lat A (76343-89-0) + 15,17-Dimethoxy-15,O-seco-Lat A Carboxylic Acid (122898-77-5)

Guidance literature:

With boron trifluoride diethyl etherate; for 12h; Ambient temperature;

Reference yield:

methanol (67-56-1) + Latrunculin A (76343-93-6) → 4-((4Z,8E,10Z)-(1R,12S,15R,17R)-17-Methoxy-5,12-dimethyl-3-oxo-2,16-dioxa-bicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-thiazolidin-2-one (76343-89-0,127852-19-1)

Guidance literature:

With sulfuric acid; 1.) 30 min, 0 deg C; 2.) 2 h, room temp.;

DOI:10.1021/jo00168a028

upstream raw materials:

methanol

latrunculin A

Latrunculin-A

Latrunculin A

Downstream raw materials:

17-O-methyl-N-benzyllatrunculin A

17-O-methyl-N-benzoyllatrunculin A

17-O-methyl-N-(6'-methoxyphenylacetyl)latrunculin A

latrunculin A

Refernces

• 1、 Khanfar, Mohammad A.,Youssef, Diaa T. A.,El Sayed, Khalid A.. "Semisynthetic latrunculin derivatives as inhibitors of metastatic breast cancer: Biological evaluations, preliminary structure-activity relationship and molecular modeling studies". experimental part. p. 274 - 285. Retrieved 2010/11/16.
• 2、 Groweiss, Amiram,Shmueli, Uri,Kashman, Yoel. "Marine Toxins of Latrunculia magnifica". . p. 3512 - 3516. Retrieved 2007/10/02.